PMID- 21188849 OWN - NLM STAT- MEDLINE DCOM- 20110401 LR - 20201209 IS - 1536-5409 (Electronic) IS - 0749-8047 (Linking) VI - 27 IP - 1 DP - 2011 Jan TI - Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. PG - 1-8 AB - OBJECTIVE: This study was conducted to evaluate the dose range of etoricoxib in acute pain using the postoperative dental pain model further. METHODS: This double-blind, randomized controlled study evaluated etoricoxib (90 and 120 mg), ibuprofen (600 mg), and acetaminophen (600 mg/codeine) (60 mg, (A/C)) in patients aged >/= 18 years with moderate or severe pain after surgical extraction of >/= 2 third molars (>/= 1 impacted). The patients reported pain intensity and pain relief over 24 hours. The primary efficacy endpoint was total pain relief over 6 hours (TOPAR6). Adverse events were evaluated throughout the study. RESULTS: There were 588 patients randomized to placebo (n=46),etoricoxib (90 mg (n=191)), etoricoxib (120 mg (n=97)), ibuprofen(2400 mg (n=192)), and A/C (n=62). The overall analgesic effect (TOPAR6) of etoricoxib (90, 120 mg) was significantly greater than that of placebo (P