PMID- 21189067
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 15
IP  - 1-2
DP  - 2011 Jan-Feb
TI  - Human leukocyte antigen-DRB1 class II genes in Mexican Amerindian Mazahuas: genes 
      and languages do not correlate.
PG  - 97-102
LID - 10.1089/gtmb.2010.0055 [doi]
AB  - BACKGROUND: The major histocompatibility complex genes are located on the short 
      arm of the human sixth chromosome; they are highly polymorphic and therefore have 
      been very advantageous in population genetic studies. METHODS: A Mazahua group 
      established in North Mexico State and also in nearby Michoacan state in the rainy 
      mountain highlands (Mexico) was studied for their human leukocyte antigen 
      (HLA)-DRB1 alleles. The relationship with other Amerindians and worldwide 
      populations was studied by using 14,996 chromosomes from 75 different populations 
      and calculating neighbor-joining dendrograms and correspondence multidimensional 
      values. RESULTS: Five principal HLA allele frequencies were found in our group: 
      DRB1*0802 (the most frequent one in this population), DRB1*0407, DRB1*0403, 
      DRB1*0101, and DRB1*1406. Both genetic distances and correspondence analyses 
      clearly show that our Mazahua group is genetically close to some of the most 
      ancient groups living in Mexico (Mayos, Zapotecans, Tennek) and South American 
      Amerindians. Amerindians remain as a group apart from the rest of the world. 
      CONCLUSIONS: The results analyzing the HLA-DR locus suggest that Mazahua language 
      (Otomangue) does not correlate with those of the most closely HLA-correlated 
      ethnic groups. The present data may be useful for future transplantation 
      programs, HLA and disease diagnosis, and pharmacogenetic studies.
FAU - Arnaiz-Villena, Antonio
AU  - Arnaiz-Villena A
AD  - Department of Immunology, University Complutense, The Madrid Regional Blood 
      Center, Madrid, Spain. aarnaiz@med.ucm.es
FAU - Abd-El-Fatah, Sedeka
AU  - Abd-El-Fatah S
FAU - Granados-Silvestre, Maria Angeles
AU  - Granados-Silvestre MA
FAU - Parga-Lozano, Carlos
AU  - Parga-Lozano C
FAU - Gomez-Prieto, Pablo
AU  - Gomez-Prieto P
FAU - Rey, Diego
AU  - Rey D
FAU - Areces, Cristina
AU  - Areces C
FAU - Penaranda, Patricia
AU  - Penaranda P
FAU - Menjivar, Martha
AU  - Menjivar M
FAU - Rodriguez-Perez, Jose Manuel
AU  - Rodriguez-Perez JM
FAU - Granados, Julio
AU  - Granados J
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101228
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Genes, MHC Class II/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Language
MH  - Mexico/ethnology
MH  - Population Groups/genetics
EDAT- 2010/12/30 06:00
MHDA- 2011/07/20 06:00
CRDT- 2010/12/30 06:00
PHST- 2010/12/30 06:00 [entrez]
PHST- 2010/12/30 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 10.1089/gtmb.2010.0055 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2011 Jan-Feb;15(1-2):97-102. doi: 
      10.1089/gtmb.2010.0055. Epub 2010 Dec 28.