PMID- 21189593
OWN - NLM
STAT- MEDLINE
DCOM- 20121206
LR  - 20131121
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 19
IP  - 3
DP  - 2003 Aug
TI  - [Effects of central and peripheral administration of a nitric oxide synthase 
      inhibitor on AVP-induced hypothermia in rats].
PG  - 261-4
AB  - AIM: To explore the role of nitric oxide (NO) in arginine vasopressin 
      (AVP)-induced hypothermia. METHODS: Colonic temperature was measured at 30 min 
      intervals with a digital thermometer. Effects of central and peripheral 
      administration of nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine 
      methyl ester (L-NAME) on AVP-induced hypothermia were observed in rats. RESULTS: 
      (1) Intravenous injection (i.v.) of AVP (4 microg x kg(-1)) and L-NAME (30 mg x 
      kg(-1)) produced a significant drop in body temperature, respectively. 
      Coadministration of L-NAME i.v. with AVP i.v. did not significantly influence the 
      magnitude of AVP-induced hypothermia. (2) Intracerebroventricular (i.c.v.) 
      injection of L-NAME (1 mg x kg(-1)) caused a significant increase in body 
      temperature, but when the treatments with AVP and L-NAME were combined, i.c.v. 
      injection of L-NAME markedly blocked the hypothermic effect of AVP intravenous 
      injection. CONCLUSION: Endogenous NO in the central nervous system plays a major 
      role in AVP-induced hypothermia. In addition, central NO seems to play a tonic 
      thermoregulatory role by reducing normal body temperature because an increase in 
      body temperature was observed after treatment with NOS inhibitor L-NAME.
FAU - Yang, Yong-Lu
AU  - Yang YL
AD  - Lanzhou Military Medical College of PLA, Lanzhou 730020, China.
FAU - Yang, Zhen
AU  - Yang Z
FAU - Li, Xiao-Ming
AU  - Li XM
FAU - Li, Yu-Shan
AU  - Li YS
FAU - Luo, Xiao-Hong
AU  - Luo XH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Enzyme Inhibitors)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Body Temperature/*drug effects
MH  - Body Temperature Regulation/drug effects
MH  - Enzyme Inhibitors/*pharmacology
MH  - Hypothermia/*chemically induced
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/*pharmacology
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Wistar
EDAT- 2003/08/01 00:00
MHDA- 2012/12/10 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2003/08/01 00:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003 Aug;19(3):261-4.