PMID- 21190051
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20211020
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 118
IP  - 2
DP  - 2011 Feb
TI  - Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic 
      variants on hippocampal volume and memory performance in healthy young adults.
PG  - 249-57
LID - 10.1007/s00702-010-0539-8 [doi]
AB  - Unravelling the impact of genetic variants on clinical phenotypes is a 
      challenging task. Apolipoprotein E (ApoE) and brain-derived neurotrophic factor 
      (BDNF) play an important role in cell growth, regeneration, synaptic plasticity, 
      learning and memory processes. The aim of the present study was to examine the 
      impact of BDNF Val66Met- and ApoE-polymorphisms and their interactions on 
      hippocampal morphology and memory functions in healthy young adults. Hippocampal 
      volume and memory performance of 135 healthy individuals, aged 24.6 +/- 3.2 years, 
      were assessed, using magnetic resonance imaging and the Inventory for Memory 
      diagnostics. The performance of BDNF-Met66 carriers was significantly lower in 
      working memory (P = 0.03) compared with non carriers, whereas no further 
      differences were observed either in cognitive performance or in hippocampal 
      volumes between the groups. Age, BDNF Val66 Met polymorphism and the interaction 
      factor BDNF genotype x age were significantly associated with the variation of 
      working memory scores (P = 0.01, 0.01, 0.02 respectively). No statistically 
      significant differences were detected in the volumes of hippocampi and in memory 
      phenotypes between individuals carrying the ApoE E4 allele and those without it. 
      The analysis did not reveal an impact of gene-gene interaction between BDNF and 
      ApoE genes on hippocampal volumes or memory performance. BDNF Val66Met 
      polymorphism seems to influence working memory function and modulate the effects 
      of ageing on working memory in healthy young adults.
FAU - Richter-Schmidinger, Tanja
AU  - Richter-Schmidinger T
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universitat 
      Erlangen-Nurnberg, Erlangen, Germany.
FAU - Alexopoulos, Panagiotis
AU  - Alexopoulos P
FAU - Horn, Marco
AU  - Horn M
FAU - Maus, Sebastian
AU  - Maus S
FAU - Reichel, Martin
AU  - Reichel M
FAU - Rhein, Cosima
AU  - Rhein C
FAU - Lewczuk, Piotr
AU  - Lewczuk P
FAU - Sidiropoulos, Christos
AU  - Sidiropoulos C
FAU - Kneib, Thomas
AU  - Kneib T
FAU - Perneczky, Robert
AU  - Perneczky R
FAU - Doerfler, Arnd
AU  - Doerfler A
FAU - Kornhuber, Johannes
AU  - Kornhuber J
LA  - eng
PT  - Journal Article
DEP - 20101229
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Apolipoproteins E/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Male
MH  - Memory/*physiology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Young Adult
EDAT- 2010/12/31 06:00
MHDA- 2011/08/13 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2010/11/14 00:00 [accepted]
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.1007/s00702-010-0539-8 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2011 Feb;118(2):249-57. doi: 10.1007/s00702-010-0539-8. 
      Epub 2010 Dec 29.