PMID- 21190521
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20220330
IS  - 1875-5550 (Electronic)
IS  - 1389-2037 (Print)
IS  - 1389-2037 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - Role of mTOR signaling in tumor cell motility, invasion and metastasis.
PG  - 30-42
AB  - Tumor cell migration and invasion play fundamental roles in cancer metastasis. 
      The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously 
      expressed serine/threonine (Ser/Thr) kinase, is a central regulator of cell 
      growth, proliferation, differentiation and survival. Recent studies have shown 
      that mTOR also plays a critical role in the regulation of tumor cell motility, 
      invasion and cancer metastasis. Current knowledge indicates that mTOR functions 
      as two distinct complexes, mTORC1 and mTORC2. mTORC1 phosphorylates p70 S6 kinase 
      (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), 
      and regulates cell growth, proliferation, survival and motility. mTORC2 
      phosphorylates Akt, protein kinase C alpha (PKCalpha) and the focal adhesion proteins, 
      and controls the activities of the small GTPases (RhoA, Cdc42 and Rac1), and 
      regulates cell survival and the actin cytoskeleton. Here we briefly review recent 
      knowledge of mTOR complexes and the role of mTOR signaling in tumor cell 
      migration and invasion. We also discuss recent efforts about the mechanism by 
      which rapamycin, a specific inhibitor of mTOR, inhibits cell migration, invasion 
      and cancer metastasis.
FAU - Zhou, Hongyu
AU  - Zhou H
AD  - Department of Biochemistry and Molecular Biology, Louisiana State University 
      Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
FAU - Huang, Shile
AU  - Huang S
LA  - eng
GR  - R01 CA115414/CA/NCI NIH HHS/United States
GR  - CA115414/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Protein Pept Sci
JT  - Current protein & peptide science
JID - 100960529
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Cell Movement
MH  - Humans
MH  - Neoplasm Invasiveness/*physiopathology
MH  - Neoplasm Metastasis/*physiopathology
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3410744
MID - NIHMS377915
EDAT- 2010/12/31 06:00
MHDA- 2011/08/02 06:00
PMCR- 2012/08/02
CRDT- 2010/12/31 06:00
PHST- 2010/12/10 00:00 [received]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
PHST- 2012/08/02 00:00 [pmc-release]
AID - CPPS-88 [pii]
AID - 10.2174/138920311795659407 [doi]
PST - ppublish
SO  - Curr Protein Pept Sci. 2011 Feb;12(1):30-42. doi: 10.2174/138920311795659407.