PMID- 21193364
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20110725
IS  - 1877-783X (Electronic)
IS  - 1877-7821 (Linking)
VI  - 35
IP  - 4
DP  - 2011 Aug
TI  - Cytogenetic and comparative genomic hybridization study of Indian myelodysplastic 
      syndromes.
PG  - e1-5
LID - 10.1016/j.canep.2010.11.009 [doi]
AB  - INTRODUCTION: Myelodysplastic syndromes (MDSs) are clonal stem cell disorders 
      characterized by cytopenias, dysplasia in one or more cell lineages and 
      ineffective hematopoiesis and are associated with significant morbidity and 
      mortality due to bone marrow failure or evolution to acute myeloid leukemia. 
      Clonal chromosomal abnormalities are detected in 40-60% of patients. Multiple 
      recurrent chromosomal aberrations have been identified by cytogenetics including 
      fluorescence in situ hybridization (FISH) which is now widely recognized as one 
      of the most important diagnostic and prognostic markers in MDS. METHODS: 
      Conventional cytogenetics by GTG-banding, FISH, comparative genomic hybridization 
      (CGH) was done on 40 primary MDS subjects. RESULTS: Among 40 subjects, 10 (25%) 
      were abnormal and 30 (75%) showed apparently normal karyotypes with GTG banding 
      and FISH. The various aberrations observed were del 5q-, del 7q-, 20q-, +8. DNA 
      copy number changes including losses (30%) and gains (20%) were detected by CGH 
      in 11 (36.6%) out of 30 karyotypically normal MDS. However chromosome 7 (37%) and 
      1 (25%) is frequently involved in current study population. CONCLUSIONS: This 
      study confirms that the apart from non-random chromosome aberrations, other 
      chromosome regions also involved in the MDS development. The occupational, 
      environmental and geographical variations might be influencing the disease. 
      Furthermore cytogenetic studies are warranted in larger groups of MDS cases to 
      identify newly acquired chromosome aberrations that may aid in cloning new genes 
      involved in the neoplastic process, ultimately helping in the development of 
      targeted therapeutic drugs.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Kawankar, Nikesh
AU  - Kawankar N
AD  - Department of Cytogenetics, National Institute of Immunohaematology (ICMR), 13th 
      Floor, Newmultistoryed Building, K.E.M. Hospital Campus, Parel, Mumbai 400012, 
      India.
FAU - Jijina, Farah
AU  - Jijina F
FAU - Ghosh, Kanjaksha
AU  - Ghosh K
FAU - Vundinti, Babu Rao
AU  - Vundinti BR
LA  - eng
PT  - Journal Article
DEP - 20101228
PL  - Netherlands
TA  - Cancer Epidemiol
JT  - Cancer epidemiology
JID - 101508793
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Comparative Genomic Hybridization/methods
MH  - Cytogenetics/methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - India
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Young Adult
EDAT- 2011/01/05 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/07/16 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - S1877-7821(10)00209-2 [pii]
AID - 10.1016/j.canep.2010.11.009 [doi]
PST - ppublish
SO  - Cancer Epidemiol. 2011 Aug;35(4):e1-5. doi: 10.1016/j.canep.2010.11.009. Epub 
      2010 Dec 28.