PMID- 21194614
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20131121
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 105
IP  - 2
DP  - 2011 Feb
TI  - Organogallium(III) complexes as apoptosis promoting anticancer agents for head 
      and neck squamous cell carcinoma (HNSCC) cell lines.
PG  - 164-70
LID - 10.1016/j.jinorgbio.2010.10.013 [doi]
AB  - Organogallium(III) dinuclear (1-9) and tetranuclear (10) complexes present 
      potential therapeutic agents for the treatment of various types of cancer. The 
      antiproliferative activity of 1-10 was evaluated with cell lines of head and neck 
      squamous cell carcinomas, e.g. HN (soft palate), Cal27, Cal33 (tongue) and FaDu 
      (hypopharynx) cell lines. The activity of compound 8 is comparable with that of 
      cisplatin on cell line Cal27 (IC(50) 4.6 muM for both compounds). The mode of cell 
      death induced, caspase activity and cell cycle analysis were evaluated for 
      potential hit compounds 3, 5 and 8 Potential hit compounds 3, 5 and 8 were 
      further evaluated for the mode of cell death, caspase activity and cell cycle 
      analysis. Apoptosis induced by compounds 3, 5 and 8 on Cal27 and FaDu cells was 
      confirmed by DNA laddering , as well as acridine orange (AO) and ethidium bromide 
      (EB) double staining. These compounds (3, 5 and 8) induced caspase-independent 
      apoptosis (within 4 h of action) in cell line Cal27. Extrinsic-mediated apoptosis 
      associated with caspase 8 and 3 activation is the main mode of cytotoxicity 
      induced on FaDu cells by compounds 3, 5 and 8. Cell cycle perturbations caused by 
      these compounds are also observed. Our data suggest that compounds 3, 5 and 8 
      should be studied further for the treatment of head and neck cancer.
CI  - Copyright A(c) 2010 Elsevier Inc. All rights reserved.
FAU - Kaluderovic, Milena R
AU  - Kaluderovic MR
AD  - Department of Oral, Maxillofacial and Facial Plastic Surgery, University of 
      Leipzig, Nurnberger Str. 57, D-04103 Leipzig, Germany.
FAU - Kaluderovic, Goran N
AU  - Kaluderovic GN
FAU - Gomez-Ruiz, Santiago
AU  - Gomez-Ruiz S
FAU - Paschke, Reinhard
AU  - Paschke R
FAU - Hemprich, Alexander
AU  - Hemprich A
FAU - Kuhling, Jan
AU  - Kuhling J
FAU - Remmerbach, Torsten W
AU  - Remmerbach TW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101030
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Coordination Complexes)
RN  - CH46OC8YV4 (Gallium)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Antineoplastic Agents/chemistry/*pharmacology
MH  - Apoptosis
MH  - Carcinoma, Squamous Cell
MH  - Caspases/metabolism
MH  - Cell Cycle/drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Coordination Complexes/chemistry/*pharmacology
MH  - DNA Fragmentation/drug effects
MH  - Drug Screening Assays, Antitumor
MH  - *Gallium
MH  - Head and Neck Neoplasms
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Structure-Activity Relationship
EDAT- 2011/01/05 06:00
MHDA- 2011/05/17 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/07/19 00:00 [received]
PHST- 2010/10/24 00:00 [revised]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - S0162-0134(10)00241-2 [pii]
AID - 10.1016/j.jinorgbio.2010.10.013 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2011 Feb;105(2):164-70. doi: 10.1016/j.jinorgbio.2010.10.013. 
      Epub 2010 Oct 30.