PMID- 21194851
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20220309
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 207
IP  - 2
DP  - 2011 Feb 15
TI  - High podoplanin expression in cancer cells predicts lower incidence of nodal 
      metastasis in patients with lung squamous cell carcinoma.
PG  - 111-5
LID - 10.1016/j.prp.2010.11.006 [doi]
AB  - Podoplanin is expressed in a variety of malignant cells, and is generally 
      regarded as a factor promoting tumor progression in conventional studies. 
      Conversely, a recent clinicopathological study has revealed that low podoplanin 
      in cancer cells was correlated with poor prognosis of patients with stage IB lung 
      squamous cell carcinoma (LSCC). We here evaluated the clinicopathological 
      relationship between cancer-cell podoplanin expression and clinicopathological 
      parameters in 40 cases of LSCC (stage I-III). Immunohistochemical podoplanin 
      expression significantly correlated with N classification and pathological stage, 
      but not with other clinicopathological parameters. Notably, all 16 cases with 
      high podoplanin expression unexceptionally exhibited pathological N0 status. 
      Cases without nodal metastasis showed a significantly higher podoplanin-positive 
      score. Furthermore, patients with high podoplanin expression exhibited a 
      significantly longer survival time and disease-free time. These findings suggest 
      that immunohistochemical analysis for podoplanin may serve as a marker of risk of 
      nodal metastasis and prognosis in patients with LSCC.
CI  - Copyright (c) 2010 Elsevier GmbH. All rights reserved.
FAU - Suzuki, Hanako
AU  - Suzuki H
AD  - Division of Pathophysiological and Experimental Pathology, Department of 
      Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 
      Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Onimaru, Mitsuho
AU  - Onimaru M
FAU - Koga, Takaomi
AU  - Koga T
FAU - Takeshita, Masafumi
AU  - Takeshita M
FAU - Yano, Tokujiro
AU  - Yano T
FAU - Maehara, Yoshihiko
AU  - Maehara Y
FAU - Nakamura, Seiji
AU  - Nakamura S
FAU - Sueishi, Katsuo
AU  - Sueishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101230
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (PDPN protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*chemistry/mortality/secondary
MH  - Chi-Square Distribution
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*chemistry/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Membrane Glycoproteins/*analysis
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Time Factors
MH  - Up-Regulation
EDAT- 2011/01/05 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/10/18 00:00 [revised]
PHST- 2010/11/25 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S0344-0338(10)00270-0 [pii]
AID - 10.1016/j.prp.2010.11.006 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2011 Feb 15;207(2):111-5. doi: 10.1016/j.prp.2010.11.006. Epub 
      2010 Dec 30.