PMID- 21195133
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 490
IP  - 3
DP  - 2011 Mar 3
TI  - Role of different types of potassium channels and peroxisome 
      proliferator-activated receptors gamma in the antidepressant-like activity of bis 
      selenide in the mouse tail suspension test.
PG  - 205-8
LID - 10.1016/j.neulet.2010.12.053 [doi]
AB  - In the present study we investigated the role of potassium (K(+)) channels and 
      peroxisome proliferator-activated receptor gamma (PPARgamma) in the 
      antidepressant-like effect of bis selenide in the mouse tail suspension test 
      (TST). Intracerebroventricular (i.c.v.) pretreatment with tetraethyl ammonium 
      (TEA, a non-specific inhibitor of K(+) channels, 25 pg/site), glibenclamide (an 
      ATP-sensitive K(+) channel inhibitor, 0.5 pg/site), charybdotoxin (a large and 
      intermediate conductance calcium-activated K(+) channel inhibitor, 25 pg/site) or 
      apamin (a small-conductance calcium-activated K(+) channel inhibitor, 10 pg/site) 
      produced a synergistic action with a sub effective dose of bis selenide (0.1 
      mg/kg, per oral--p.o.). Picrotoxin (1 mg/kg, intraperitoneally--i.p.) 
      pretreatment did not prevent the reduction in immobility time elicited by bis 
      selenide (1 mg/kg, p.o.) in the TST. The reduction in the immobility time 
      elicited by an effective dose of bis selenide (1 mg/kg, p.o.) was prevented by 
      the pretreatment of mice with cromakalim, minoxidil (K(+) channel openers, 10 
      mug/site, i.c.v.) and GW 9662 (a PPARgamma antagonist, 10 mug/site, i.c.v.). The 
      findings clearly suggest that an acute oral dose of bis selenide produced an 
      antidepressant-like effect in the mouse TST by a mechanism that involves the K(+) 
      channels and PPARgamma receptors.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Jesse, Cristiano R
AU  - Jesse CR
AD  - Laboratorio de Sintese, Reatividade e Avaliacao Farmacologica e Toxicologica de 
      Organocalcogenios, Centro de Ciencias Naturais e Exatas, Universidade Federal de 
      Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
FAU - Wilhelm, Ethel A
AU  - Wilhelm EA
FAU - Bortolatto, Cristiani F
AU  - Bortolatto CF
FAU - Nogueira, Cristina W
AU  - Nogueira CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101230
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 ((Z)-2,3-bis(4-chlorophenylselanyl)prop-2-en-1-ol)
RN  - 0 (2-chloro-5-nitrobenzanilide)
RN  - 0 (Anilides)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (PPAR gamma)
RN  - 0 (Potassium Channel Blockers)
RN  - 0 (Potassium Channels)
RN  - 0G4X367WA3 (Cromakalim)
SB  - IM
MH  - Analysis of Variance
MH  - Anilides/pharmacology
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal
MH  - Cromakalim/pharmacology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Freezing Reaction, Cataleptic/*drug effects
MH  - Hindlimb Suspension/*methods
MH  - Male
MH  - Mice
MH  - Organoselenium Compounds/chemistry/*pharmacology
MH  - PPAR gamma/antagonists & inhibitors/*metabolism
MH  - Potassium Channel Blockers/pharmacology
MH  - Potassium Channels/*metabolism
EDAT- 2011/01/05 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/08/09 00:00 [received]
PHST- 2010/12/20 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - S0304-3940(10)01623-X [pii]
AID - 10.1016/j.neulet.2010.12.053 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Mar 3;490(3):205-8. doi: 10.1016/j.neulet.2010.12.053. Epub 
      2010 Dec 30.