PMID- 21195291
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110103
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 19 Suppl 1
DP  - 2011 Jan
TI  - Carthami-Semen acupuncture point injection for chronic daily headache: a pilot, 
      randomised, double-blind, controlled trial.
PG  - S19-25
LID - 10.1016/j.ctim.2010.09.004 [doi]
AB  - OBJECTIVES: This study was conducted to examine the possibility of Carthami-Semen 
      (CS, Safflower seed) acupuncture point injection as a new promising treatment for 
      chronic daily headache (CDH). METHODS: A total of 40 subjects with CDH were 
      recruited and randomised to a CS acupuncture point injection group or a normal 
      saline (NS) acupuncture point injection group. Acupuncture point injections were 
      applied twice a week during 4 weeks to the bilateral Fengchi (GB20), Jianjing 
      (GB21) and Taiyang (EX-HN5) acupoints with CS extract or NS. OUTCOME MEASURES: 
      The primary outcome measure was headache-related quality of life (QoL), assessed 
      using the Headache Impact Test (HIT). Secondary outcome measures were the changes 
      in the number of headache-free days and health status as assessed with the Short 
      Form (36) Health Survey (SF-36). RESULTS: HIT scores decreased by 14.9 points in 
      the CS acupuncture point injection group compared with 7.9 points in the NS 
      acupuncture point injection group (p=0.013). Headache-free days increased by 
      32.6% in the CS acupuncture point injection group compared with 17.4% in the NS 
      acupuncture point injection group (p=0.045). There were significant increases in 
      SF-36 scores compared with baseline in both groups, but the mean improvement was 
      greater in the CS acupuncture point injection group. No serious adverse events 
      (AEs) were reported. CONCLUSIONS: We suggest that the CS acupuncture point 
      injection could be a new safe and promising treatment for CDH. A larger and 
      long-term follow-up trial is needed to determine more definitely the efficacy of 
      CS acupuncture point injection and to elucidate how long the effect lasts.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Park, Jung-Mi
AU  - Park JM
AD  - Department of Cardiovascular & Neurologic Diseases, College of Korean Medicine, 
      Kyung-Hee University, Seoul, Republic of Korea.
FAU - Park, Seong-Uk
AU  - Park SU
FAU - Jung, Woo-Sang
AU  - Jung WS
FAU - Moon, Sang-Kwan
AU  - Moon SK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101012
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - *Acupuncture Points
MH  - *Acupuncture Therapy
MH  - Adult
MH  - *Carthamus tinctorius
MH  - Double-Blind Method
MH  - Drugs, Chinese Herbal/administration & dosage/*therapeutic use
MH  - Female
MH  - Headache Disorders/*therapy
MH  - Health Status
MH  - Humans
MH  - Injections
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - *Quality of Life
MH  - Seeds
MH  - Treatment Outcome
EDAT- 2011/01/05 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/01/04 06:00
PHST- 2009/09/25 00:00 [received]
PHST- 2010/07/09 00:00 [revised]
PHST- 2010/09/03 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - S0965-2299(10)00100-7 [pii]
AID - 10.1016/j.ctim.2010.09.004 [doi]
PST - ppublish
SO  - Complement Ther Med. 2011 Jan;19 Suppl 1:S19-25. doi: 10.1016/j.ctim.2010.09.004. 
      Epub 2010 Oct 12.