PMID- 21195419
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20211203
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 174
IP  - 1
DP  - 2012 May 1
TI  - Alternate day calorie restriction improves systemic inflammation in a mouse model 
      of sepsis induced by cecal ligation and puncture.
PG  - 136-41
LID - 10.1016/j.jss.2010.11.883 [doi]
AB  - BACKGROUND: Calorie restriction (CR) exerts cytoprotective effects by 
      up-regulating survival factors, such as mammalian target of rapamycin (mTOR), 
      sirtuin, and peroxisome proliferator-activated receptor-gamma co-activator 1alpha 
      (PGC-1alpha). These survival factors have well-established roles in attenuating the 
      inflammatory response. However, it is unclear whether CR affects sepsis-related 
      inflammation. The purpose of this study was to determine whether CR affects 
      sepsis-induced inflammation in a cecal ligation and puncture (CLP)-induced mouse 
      model of sepsis. METHODS: Male C57BL/6N mice underwent alternate day calorie 
      restriction or normal feeding for 8 d before CLP-induced sepsis. After induction 
      of sepsis, liver and lung histopathology and serum levels of cytokines and 
      survival factors were assessed. RESULTS: Serum cytokine and high mobility group 
      box protein 1 (HMGB1) levels were lower in animals that underwent alternate day 
      calorie restriction compared with normally-fed mice after CLP. Alternate day 
      calorie restriction also increased levels of sirtuin, PGC-1alpha, and mTOR. While 80% 
      of mice in the CLP group died within 48 h after undergoing CLP, 50% of mice died 
      in the ACR + CLP group (P < 0.05). CONCLUSION: Alternate day calorie restriction 
      decreased mortality in a mouse model of sepsis. In addition to attenuated organ 
      injury, a significant reduction in cytokine and HMGB1 levels was observed. These 
      findings suggest that alternative day calorie restriction may reduce excessive 
      inflammation.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Hasegawa, Akira
AU  - Hasegawa A
AD  - Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty 
      of Medicine, Yufu City, Oita, Japan.
FAU - Iwasaka, Hideo
AU  - Iwasaka H
FAU - Hagiwara, Satoshi
AU  - Hagiwara S
FAU - Asai, Nobuhiko
AU  - Asai N
FAU - Nishida, Taichi
AU  - Nishida T
FAU - Noguchi, Takayuki
AU  - Noguchi T
LA  - eng
PT  - Journal Article
DEP - 20101209
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (HSP72 Heat-Shock Proteins)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Cecum/surgery
MH  - Cytokines/blood
MH  - Disease Models, Animal
MH  - HMGB1 Protein/blood
MH  - HSP72 Heat-Shock Proteins/analysis
MH  - Inflammation/*prevention & control
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Sepsis/*complications/metabolism
MH  - Sirtuins/analysis
MH  - TOR Serine-Threonine Kinases/analysis
MH  - Trans-Activators/analysis
MH  - Transcription Factors
EDAT- 2011/01/05 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/07/04 00:00 [received]
PHST- 2010/10/16 00:00 [revised]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - S0022-4804(10)01807-X [pii]
AID - 10.1016/j.jss.2010.11.883 [doi]
PST - ppublish
SO  - J Surg Res. 2012 May 1;174(1):136-41. doi: 10.1016/j.jss.2010.11.883. Epub 2010 
      Dec 9.