PMID- 21195488
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20240504
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 233
IP  - 1-2
DP  - 2011 Apr
TI  - Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.
PG  - 185-91
LID - 10.1016/j.jneuroim.2010.11.005 [doi]
AB  - Few studies have examined the relationship between human leukocyte antigen (HLA) 
      polymorphisms and adult glioma, particularly at class II loci. We evaluated the 
      association between selected HLA class II polymorphisms and adult glioma in a 
      large, hospital-based case-control study, using unconditional logistic 
      regression. DQB1 06 (OR=1.67, 95% CI=1.17-2.39) and DRB1 13 (OR=1.69, 95% 
      CI=1.08-2.64) alleles were associated with an increased risk of glioma, while the 
      DQB1 05 allele showed an inverse association (OR=0.63, 95% CI=0.43-0.93). These 
      results, which were of borderline significance once controlled for the false 
      discovery rate, suggest a potential role for the DQB1 06, DQB1 05, and DRB1 13 
      alleles in glioma susceptibility.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Bassig, Bryan A
AU  - Bassig BA
AD  - Yale School of Public Health, Yale School of Medicine, 60 College Street, P.O. 
      Box 208034, New Haven, CT 06510, USA.
FAU - Inskip, Peter D
AU  - Inskip PD
FAU - Burdette, Laurie
AU  - Burdette L
FAU - Shapiro, William R
AU  - Shapiro WR
FAU - Selker, Robert G
AU  - Selker RG
FAU - Fine, Howard A
AU  - Fine HA
FAU - Loeffler, Jay S
AU  - Loeffler JS
FAU - Black, Peter M
AU  - Black PM
FAU - Dubrow, Robert
AU  - Dubrow R
FAU - Brenner, Alina V
AU  - Brenner AV
LA  - eng
GR  - Z99 CA999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20101230
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*genetics/*immunology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Glioma/*genetics/*immunology
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics/immunology
PMC - PMC3074044
MID - NIHMS256493
EDAT- 2011/01/05 06:00
MHDA- 2011/06/08 06:00
PMCR- 2012/04/01
CRDT- 2011/01/04 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/11/10 00:00 [revised]
PHST- 2010/11/15 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - S0165-5728(10)00516-3 [pii]
AID - 10.1016/j.jneuroim.2010.11.005 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2011 Apr;233(1-2):185-91. doi: 10.1016/j.jneuroim.2010.11.005. 
      Epub 2010 Dec 30.