PMID- 21195999
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20161031
IS  - 2213-3941 (Electronic)
IS  - 0003-4266 (Linking)
VI  - 72
IP  - 1
DP  - 2011 Feb
TI  - Graves' ophthalmopathy after total thyroidectomy for papillary carcinoma.
PG  - 42-4
LID - 10.1016/j.ando.2010.11.001 [doi]
AB  - We report the case of a 53-year-old woman who underwent two-phase total 
      thyroidectomy (June and December 2001) for a multinodular goiter with incidental 
      discovery at the first procedure of a multicentric papillary carcinoma of the 
      right thyroid lobe. Thyroidectomy was followed by an ablative dose of 
      131-radioiodine because of the presence of residual tissue in the neck. The 
      various elements of the follow-up are reassuring: no residual tissue was detected 
      at the ultrasonography of the neck and thyroglobulin was undetectable in the 
      absence of antithyroglobulin autoantibodies. In April 2006, the patient developed 
      unilateral Graves' ophthalmopathy with the appearance of antithyrotropin receptor 
      autoantibodies (TRAb). Ophthalmopathy progressively improved, in parallel to the 
      decrease of TRAb. The parallel trend of TRAb and the ophthalmopathy supports the 
      major role of TRAb in the pathogenesis of thyroid-associated ophthalmopathy. This 
      observation also shows the possibility of developing autoantibodies in the 
      absence of detectable thyroid tissue.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Giovansili, L
AU  - Giovansili L
AD  - Service de medecine interne, fondation ophtalmologique A de Rothschild, 75019 
      Paris, France. lamaendoc@hotmail.com
FAU - Cayrolle, G
AU  - Cayrolle G
FAU - Belange, G
AU  - Belange G
FAU - Clavel, G
AU  - Clavel G
FAU - Herdan, M-L
AU  - Herdan ML
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101231
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Thyroid-Stimulating)
RN  - 0 (Receptors, Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Autoantibodies/pharmacology
MH  - Carcinoma, Papillary/complications/pathology/*surgery
MH  - Female
MH  - Graves Ophthalmopathy/*etiology
MH  - Humans
MH  - Immunoglobulins, Thyroid-Stimulating
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Pain/etiology
MH  - Postoperative Complications/*etiology/therapy
MH  - Receptors, Thyrotropin/immunology
MH  - Thyroid Function Tests
MH  - Thyroid Neoplasms/complications/pathology/*surgery
MH  - *Thyroidectomy
MH  - Thyroxine/therapeutic use
MH  - Vision Tests
EDAT- 2011/01/05 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - S0003-4266(10)00214-3 [pii]
AID - 10.1016/j.ando.2010.11.001 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2011 Feb;72(1):42-4. doi: 10.1016/j.ando.2010.11.001. 
      Epub 2010 Dec 31.