PMID- 21197326
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 3
DP  - 2010 Nov 10
TI  - Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to 
      soft tissue injury: diclofenac epolamine topical patch.
PG  - 223-33
LID - 10.2147/JPR.S13238 [doi]
AB  - The objective of this article is to review published clinical data on diclofenac 
      epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue 
      injuries, such as strains, sprains, and contusions. Review of published 
      literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, 
      and DETP in patients with acute soft tissue injuries was included. Relevant 
      literature was identified on MEDLINE using the search terms topical NSAIDs, 
      diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, 
      strain, sprain, and contusion, and from citations in retrieved articles covering 
      the years 1978-2008. Review of published, randomized clinical trials and 
      meta-analyses shows that topical NSAIDs are significantly more effective than 
      placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% 
      confidence interval, 1.5-1.9). In a limited number of comparisons, topical and 
      oral NSAIDs provided comparable pain relief, but the use of topical agents 
      produced lower plasma drug concentrations and fewer systemic adverse events 
      (AEs). The physical-chemical properties of diclofenac epolamine make it well 
      suited for topical use. In patients with acute soft tissue injuries treated with 
      DETP, clinical data report an analgesic benefit within hours of the first 
      application, and significant pain relief relative to placebo within 3 days. 
      Moreover, DETP displayed tolerability comparable with placebo; the most common 
      AEs were pruritus and other application site reactions. Review of published 
      literature suggests that DETP is generally safe and well tolerated, clinically 
      efficacious, and a rational treatment option for patients experiencing acute pain 
      associated with strains, sprains, and contusions, and other localized painful 
      conditions.
FAU - Lionberger, David R
AU  - Lionberger DR
AD  - Southwest Orthopedic Group, Houston, TX, USA;
FAU - Brennan, Michael J
AU  - Brennan MJ
LA  - eng
PT  - Journal Article
DEP - 20101110
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC3004639
OTO - NOTNLM
OT  - contusions
OT  - diclofenac epolamine
OT  - soft tissue injury
OT  - sprains
OT  - strains
OT  - topical analgesics
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
PMCR- 2010/11/10
CRDT- 2011/01/04 06:00
PHST- 2010/11/09 00:00 [received]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
PHST- 2010/11/10 00:00 [pmc-release]
AID - jpr-3-223 [pii]
AID - 10.2147/JPR.S13238 [doi]
PST - epublish
SO  - J Pain Res. 2010 Nov 10;3:223-33. doi: 10.2147/JPR.S13238.