PMID- 21198444
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20181201
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 123
IP  - 2
DP  - 2011 Feb
TI  - Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status 
      epilepticus.
PG  - 142-6
LID - 10.1111/j.1600-0404.2010.01430.x [doi]
AB  - BACKGROUND: Lacosamide (LCM) is a novel antiepileptic drug (AED) recently 
      approved as an adjunctive therapy in the treatment of partial seizures in adults. 
      LCM is available in oral and intravenous formulations, has linear 
      pharmacokinetics and a unique mechanism of action. THE AIM OF THIS STUDY: To 
      evaluate the safety and efficacy of intravenous LCM in the treatment of 
      nonconvulsive status epilepticus (NCSE) after failure of conventional therapy. 
      METHODS: We retrospectively reviewed all patients with NCSE treated with LCM. We 
      reviewed the clinical and electrographic changes before and after LCM 
      administration. We also noted any reported side effects including 
      electrocardiographic changes. RESULTS: We report four cases of NCSE that were 
      refractory to conventional treatment, but readily responsive to LCM. No side 
      effects attributable to LCM were identified. CONCLUSIONS: Intravenous LCM may be 
      safe and efficacious as an add-on AED for the treatment of NCSE when standard 
      therapy fails.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Koubeissi, M Z
AU  - Koubeissi MZ
AD  - Department of Neurology, University Hospitals Case Medical Center, Case Western 
      Reserve University, Cleveland, OH 44106-5040, USA. 
      mohamad.koubeissi@uhhospitals.org
FAU - Mayor, C L
AU  - Mayor CL
FAU - Estephan, B
AU  - Estephan B
FAU - Rashid, S
AU  - Rashid S
FAU - Azar, N J
AU  - Azar NJ
LA  - eng
PT  - Journal Article
DEP - 20101010
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Acetamides)
RN  - 0 (Anticonvulsants)
RN  - 563KS2PQY5 (Lacosamide)
SB  - IM
MH  - Acetamides/*administration & dosage/adverse effects
MH  - Aged
MH  - Anticonvulsants/*administration & dosage/adverse effects
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Injections, Intravenous/methods
MH  - Lacosamide
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Single-Blind Method
MH  - Status Epilepticus/drug therapy
MH  - Treatment Outcome
EDAT- 2011/01/05 06:00
MHDA- 2011/04/27 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - 10.1111/j.1600-0404.2010.01430.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2011 Feb;123(2):142-6. doi: 10.1111/j.1600-0404.2010.01430.x. 
      Epub 2010 Oct 10.