PMID- 21198550
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20211020
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 162
IP  - 8
DP  - 2011 Apr
TI  - Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats.
PG  - 1770-80
LID - 10.1111/j.1476-5381.2010.01193.x [doi]
AB  - BACKGROUND AND PURPOSE: Animal models of drug-seeking suggest that exposure to 
      cues associated with self-administered drugs and drug primes might precipitate 
      relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH: 
      The effects of priming injections of dopamine and 5-HT agonists on drug-seeking 
      and effects of dopamine antagonists on methylenedioxymethamphetamine 
      (MDMA)-produced potentiation of drug-seeking following extinguished MDMA 
      self-administration were examined. KEY RESULTS: Drug-seeking was produced by 
      exposure to a light stimulus that had been paired with self-administered MDMA 
      infusions and this effect was potentiated by experimenter-administered injections 
      of the dopamine D(2) -like receptor agonist, quinpirole, the indirect agonist, 
      amphetamine and the uptake inhibitor, GBR 12909. Drug-seeking was not elicited by 
      the dopamine D(1) -like receptor agonist, SKF 81297 or the non-selective agonist, 
      apomorphine. The 5-HT receptor agonists DOI or mCPP also failed to elicit 
      drug-seeking. The 5-HT uptake inhibitor, clomipramine, attenuated drug-seeking 
      produced by the MDMA-associated stimulus but failed to alter the potentiated 
      response produced by GBR 12909. The D(1) receptor antagonist, SCH 23390 or the 
      D(2) receptor antagonist, eticlopride attenuated the potentiation of drug-seeking 
      produced by MDMA. CONCLUSIONS AND IMPLICATIONS: These data provide evidence of 
      dopaminergic mechanisms in drug-seeking following extinction of MDMA 
      self-administration. Because tissue levels of 5-HT were significantly decreased 
      following MDMA self-administration, we suggest that MDMA begins to preferentially 
      activate dopaminergic substrates to potentiate the drug-seeking response.
CI  - (c) 2011 The Authors. British Journal of Pharmacology (c) 2011 The British 
      Pharmacological Society.
FAU - Schenk, S
AU  - Schenk S
AD  - Victoria University of Wellington, School of Psychology, Wellington, New Zealand. 
      susan.schenk@vuw.ac.nz
FAU - Gittings, D
AU  - Gittings D
FAU - Colussi-Mas, J
AU  - Colussi-Mas J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Hallucinogens)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Addictive
MH  - Behavior, Animal/drug effects
MH  - Cues
MH  - Dopamine Agonists/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/*drug effects/metabolism
MH  - Receptors, Dopamine D2/*drug effects/metabolism
MH  - Self Administration
MH  - Serotonin/metabolism
PMC - PMC3081120
EDAT- 2011/01/05 06:00
MHDA- 2011/07/19 06:00
PMCR- 2012/04/01
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.2010.01193.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 2011 Apr;162(8):1770-80. doi: 10.1111/j.1476-5381.2010.01193.x.