PMID- 21203377
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20211020
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jan 1
TI  - Adolescent changes in homeostatic regulation of EEG activity in the delta and 
      theta frequency bands during NREM sleep.
PG  - 83-91
AB  - STUDY OBJECTIVES: Slow wave EEG activity in NREM sleep decreases by more than 60% 
      between ages 10 and 20 years. Slow wave EEG activity also declines across NREM 
      periods (NREMPs) within a night, and this decline is thought to represent the 
      dynamics of sleep homeostasis. We used longitudinal data to determine whether 
      these homeostatic dynamics change across adolescence. DESIGN: All-night sleep EEG 
      was recorded semiannually for 6 years. SETTING: EEG was recorded with ambulatory 
      recorders in the subjects' homes. PARTICIPANTS: Sixty-seven subjects in 2 
      cohorts, one starting at age 9 and one starting at age 12 years. MEASUREMENTS AND 
      RESULTS: For NREM delta (1-4 Hz) and theta (4-8 Hz) EEG, we tested whether the 
      proportion of spectral energy contained in the first NREMP changes with age. We 
      also tested for age changes in the parameters of the process S exponential 
      decline. For both delta and theta, the proportion of energy in the first NREMP 
      declined significantly across ages 9 to 18 years. Process S parameters SWA(0) and 
      TWA(0), respectively, represent slow wave (delta) activity and theta wave 
      activity at the beginning of the night. SWA(0) and TWA(0) declined significantly 
      (P < 0.0001) across ages 9 to 18. CONCLUSIONS: These declines indicate that the 
      intensity of the homeostatic or restorative processes at the beginning of sleep 
      diminished across adolescence. We propose that this change in sleep regulation is 
      caused by the synaptic pruning that occurs during adolescent brain maturation.
FAU - Campbell, Ian G
AU  - Campbell IG
AD  - University of California Davis, Department of Psychiatry and Behavioral Sciences, 
      Davis, CA 95618, USA. igcampbell@ucdavis.edu
FAU - Darchia, Nato
AU  - Darchia N
FAU - Higgins, Lisa M
AU  - Higgins LM
FAU - Dykan, Igor V
AU  - Dykan IV
FAU - Davis, Nicole M
AU  - Davis NM
FAU - de Bie, Evan
AU  - de Bie E
FAU - Feinberg, Irwin
AU  - Feinberg I
LA  - eng
GR  - R01 MH062521/MH/NIMH NIH HHS/United States
GR  - R01 MH62521/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110101
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
MH  - Adolescent
MH  - Aging/physiology
MH  - Alpha Rhythm/*physiology
MH  - Child
MH  - Female
MH  - Homeostasis/physiology
MH  - Humans
MH  - Male
MH  - Sleep Stages/*physiology
MH  - Theta Rhythm/*physiology
PMC - PMC3001800
OTO - NOTNLM
OT  - Development
OT  - FFT
OT  - longitudinal
OT  - maturation
EDAT- 2011/01/05 06:00
MHDA- 2011/05/07 06:00
PMCR- 2011/07/01
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.1093/sleep/34.1.83 [doi]
PST - epublish
SO  - Sleep. 2011 Jan 1;34(1):83-91. doi: 10.1093/sleep/34.1.83.