PMID- 21204904
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20211203
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 73
IP  - 4
DP  - 2011 Apr
TI  - The relationship between interferon-gamma gene polymorphism and acute kidney 
      allograft rejection.
PG  - 319-24
LID - 10.1111/j.1365-3083.2010.02506.x [doi]
AB  - Cytokine gene polymorphisms have been associated with modified gene expression 
      and cytokine production. Gamma interferon (IFN-gamma) plays an important role in the 
      pathogenesis of kidney transplant rejection. This study evaluated the association 
      between IFN-gamma gene polymorphisms and the history of acute allograft rejection in 
      53 adult first-transplant recipients receiving cadaveric kidney grafts. They were 
      followed up in a single centre until 2006, for a median time of 4 years after 
      transplantation (1-22 years). IFN-gamma gene polymorphisms +874 T/A (rs2430561) were 
      determined by polymerase chain reaction (PCR). T/T high IFN-gamma genotype was found 
      in 12, intermediate T/A in 29 and low A/A in 12 patients. Twenty-six acute kidney 
      rejection episodes were evidenced in 20 patients, of which none occurred in the 
      12 patients with low IFN-gamma genotype A/A. Age, gender, number of HLA (human 
      leukocyte antigen) mismatches, ABO blood groups, HLA, time after transplantation, 
      creatinine clearance and immunosuppressive regimens were excluded as confounding 
      factors associated with IFN-gamma genotype distribution between rejectors and 
      non-rejectors. IFN-gamma gene polymorphisms could be an important risk factor for 
      acute kidney transplant rejection, whereas the low A/A IFN-gamma genotype could be 
      protective against rejection.
CI  - (c) 2011 The Authors. Scandinavian Journal of Immunology (c) 2011 Blackwell 
      Publishing Ltd.
FAU - Zibar, L
AU  - Zibar L
AD  - University Josip Juraj Strosmayer Faculty of Medicine Osijek, Osijek, Croatia and 
      Clinical Hospital Center Osijek, Osijek, Croatia University Hospital Zagreb, 
      Zagreb, Croatia.
FAU - Wagner, J
AU  - Wagner J
FAU - Pavlinic, D
AU  - Pavlinic D
FAU - Galic, J
AU  - Galic J
FAU - Pasini, J
AU  - Pasini J
FAU - Juras, K
AU  - Juras K
FAU - Barbic, J
AU  - Barbic J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - ABO Blood-Group System/immunology
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Confounding Factors, Epidemiologic
MH  - Female
MH  - Genotype
MH  - Graft Rejection/epidemiology/*genetics/*immunology
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Interferon-gamma/*genetics/immunology
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics/*immunology
MH  - Risk Factors
MH  - Sex Factors
MH  - Tissue Donors
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2011/01/06 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 10.1111/j.1365-3083.2010.02506.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2011 Apr;73(4):319-24. doi: 10.1111/j.1365-3083.2010.02506.x.