PMID- 21205073
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20110126
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Linking)
VI  - 102
IP  - 2
DP  - 2011 Feb
TI  - Ethnoepidemiology of HTLV-1 related diseases: ethnic determinants of HTLV-1 
      susceptibility and its worldwide dispersal.
PG  - 295-301
LID - 10.1111/j.1349-7006.2010.01820.x [doi]
AB  - Human T-cell lymphotropic virus type 1 is vertically transmitted in neonatal life 
      and is causatively associated with adult T-cell leukemia (ATL) and 
      HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in adults. 
      Persistence of HTLV-1 in host T cells, clonal expansion of the HTLV-1 carrying T 
      cells, and emergence of malignantly transformed T cells are in accord with the 
      multistep model of human cancer and roles for continuous interaction between host 
      genes and environmental factors. This article reviews two lines of HTLV-1 
      investigation, one regarding worldwide surveillance of HTLV-1 infection foci by 
      serological testing and molecular analysis of HTLV-1 isolates, and the other 
      focusing on genetics of the human leukocyte antigen (HLA) that determines the 
      ethnic background of HTLV-1 permissiveness and susceptibility to ATL or HAM/TSP. 
      The serological surveillance revealed transcontinental dispersal of HTLV-1 in the 
      prehistoric era that started out of Africa, spread to Austro-Melanesia and the 
      Asian continent, then moved to North America and through to the southern edge of 
      South America. This was highlighted by an Andean mummy study that proved ancient 
      migration of paleo-mongoloid HTLV-1 from Asia to South America. Phylogenetic 
      analysis of HLA alleles provided a basis for ethnic susceptibility to HTLV-1 
      infection and associated diseases, both ATL and HAM/TSP. Ethnicity-based sampling 
      of peripheral blood lymphocytes has great potential for genome-wide association 
      studies to illuminate ethnically defined host factors for viral oncogenesis with 
      reference to HTLV-1 and other pathogenic elements causatively associated with 
      chronic disease and malignancies.
CI  - (c) 2011 Japanese Cancer Association.
FAU - Sonoda, Shunro
AU  - Sonoda S
AD  - Department of Virology International Island and Community Medicine, Faculty of 
      Medicine, Kagoshima University, Kagoshima, Japan. sumikoshunro@ybb.ne.jp
FAU - Li, Hong Chuan
AU  - Li HC
FAU - Tajima, Kazuo
AU  - Tajima K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - HTLV-I Infections/complications/*epidemiology/genetics
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/epidemiology/etiology/virology
MH  - Neoplasms/*epidemiology/*ethnology/etiology/*virology
EDAT- 2011/01/06 06:00
MHDA- 2011/03/12 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 10.1111/j.1349-7006.2010.01820.x [doi]
PST - ppublish
SO  - Cancer Sci. 2011 Feb;102(2):295-301. doi: 10.1111/j.1349-7006.2010.01820.x.