PMID- 21208017
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20210207
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 59
IP  - 6
DP  - 2010
TI  - Alterations of NO synthase isoforms in brain and kidney of rats with genetic and 
      salt hypertension.
PG  - 997-1009
AB  - Both brain and peripheral nitric oxide (NO) play a role in the control of blood 
      pressure and circulatory homeostasis. Central NO production seems to counteract 
      angiotensin II-induced enhancement of sympathetic tone. The aim of our study was 
      to evaluate NO synthase (NOS) activity and protein expression of its three 
      isoforms--neuronal (nNOS), endothelial NOS (eNOS) and inducible (iNOS)--in two 
      brain regions involved in blood pressure control (diencephalon and brainstem) as 
      well as in the kidney of young adult rats with either genetic (12-week-old SHR) 
      or salt-induced hypertension (8-week-old Dahl rats). We have demonstrated reduced 
      nNOS and iNOS expression in brainstem of both hypertensive models. In SHR this 
      abnormality was accompanied by attenuated NOS activity and was corrected by 
      chronic captopril treatment which prevented the development of genetic 
      hypertension. In salt hypertensive Dahl rats nNOS and iNOS expression was also 
      decreased in the diencephalon where neural structures important for salt 
      hypertension development are located. As far as peripheral NOS activity and 
      expression is concerned, renal eNOS expression was considerably reduced in both 
      genetic and salt-induced hypertension. In conclusions, we disclosed similar 
      changes of NO system in the brainstem (but not in the diencephalon) of rats with 
      genetic and salt-induced hypertension. Decreased nNOS expression was associated 
      with increased blood pressure due to enhanced sympathetic tone.
FAU - Hojna, S
AU  - Hojna S
AD  - Cardiovascular Research Center,Institute of Physiology, Academy of Sciences of 
      the Czech Republic, Prague, Czech Republic. silvie.hojna@post.cz
FAU - Kunes, J
AU  - Kunes J
FAU - Zicha, J
AU  - Zicha J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Isoenzymes)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Brain/*enzymology/metabolism
MH  - Hypertension/*enzymology/etiology/genetics
MH  - Isoenzymes/genetics/metabolism
MH  - Kidney/*enzymology/metabolism
MH  - Male
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase/genetics/*metabolism
MH  - Rats
MH  - Rats, Inbred Dahl
MH  - Sodium Chloride, Dietary/toxicity
EDAT- 2011/01/07 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 932064 [pii]
AID - 10.33549/physiolres.932064 [doi]
PST - ppublish
SO  - Physiol Res. 2010;59(6):997-1009. doi: 10.33549/physiolres.932064.