PMID- 21208205
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20211020
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 132
IP  - 3
DP  - 2011 Mar
TI  - Tolerogenic dendritic cells and their potential applications.
PG  - 307-14
LID - 10.1111/j.1365-2567.2010.03396.x [doi]
AB  - Dendritic cells (DCs) play a pivotal role in regulating the balance between 
      immunity and tolerance of the immune system. Recent advancements in DC biology 
      and techniques for manipulating the function of these cells have shown their 
      immense therapeutic potential for treating a variety of immune disorders. 
      Theoretically, antigen-specific tolerogenic DCs can be generated in vitro and 
      delivered to patients to correct the dysfunctional immune responses that attack 
      their own tissues or over-react to innocuous foreign antigens. However, DCs are a 
      heterogeneous population of cells with differences in cell surface makers, 
      differentiation pathways and functions. Studies are needed to examine which 
      subset of DCs can be used for what type of applications. Furthermore, most of the 
      information on tolerogenic DCs has been obtained from animal models and 
      translational studies are needed to examine how a DC therapeutic strategy can be 
      implemented clinically to modulate immunity.
CI  - (c) 2010 The Authors. Immunology (c) 2010 Blackwell Publishing Ltd.
FAU - Hu, Jim
AU  - Hu J
AD  - Physiology and Experimental Medicine Research Program, Hospital for Sick 
      Children, 555 University Avenue, Toronto, ON, Canada. Jim.Hu@utoronto.ca
FAU - Wan, Yonghong
AU  - Wan Y
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110105
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*cytology/*immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immune Tolerance/*immunology
PMC - PMC3044897
EDAT- 2011/01/07 06:00
MHDA- 2011/03/12 06:00
PMCR- 2012/03/01
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2567.2010.03396.x [doi]
PST - ppublish
SO  - Immunology. 2011 Mar;132(3):307-14. doi: 10.1111/j.1365-2567.2010.03396.x. Epub 
      2011 Jan 5.