PMID- 21208941
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20220408
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Feb
TI  - Myocardial fibrosis in isolated left ventricular non-compaction and its relation 
      to disease severity.
PG  - 170-6
LID - 10.1093/eurjhf/hfq222 [doi]
AB  - AIMS: The aim of the present study was to evaluate the prevalence and extent of 
      myocardial fibrosis in patients with isolated left ventricular non-compaction 
      (LVNC) and to determine its relation to clinical status and LV systolic function. 
      METHODS AND RESULTS: The cardiac magnetic resonance imaging (MRI) database of our 
      institution was searched for all patients with a first diagnosis of isolated 
      LVNC. The diagnosis of isolated LVNC was based on the presence of standard 
      cardiac MRI and clinical criteria. For each patient, cine and contrast-enhanced 
      cardiac MR images were analysed to evaluate LV systolic function and the 
      prevalence and extent of late gadolinium enhancement (LGE), a surrogate of 
      myocardial fibrosis. A total of 42 patients (mean age 46 +/- 20 years, 62% male) 
      were identified. Late gadolinium enhancement was observed in 23 (55%) patients 
      with isolated LVNC, occupying 4.8 +/- 6.7% of the LV mass. Both the presence and 
      extent of LGE were significantly related to the number of abnormal clinical 
      features (i.e. symptomatic status, resting electrocardiogram abnormalities, and 
      24 h Holter monitoring abnormalities; P < 0.001 and P= 0.001, respectively). 
      Similarly, LGE was more prevalent and extensive in patients with LV ejection 
      fraction (EF) < 50% compared with patients with LVEF >/= 50% (90 vs. 23%; P< 0.001 
      and 8.9 +/- 7.6 vs. 1.1 +/- 2.4%; P< 0.001, respectively). At multivariate analysis, 
      both the presence and extent of LV LGE were independently related to LVEF (beta = 
      -0.63; P < 0.001 and beta = -0.62; P< 0.001, respectively). CONCLUSION: Myocardial 
      fibrosis is related to clinical disease severity and LV systolic dysfunction in 
      isolated LVNC.
FAU - Nucifora, Gaetano
AU  - Nucifora G
AD  - Division of Cardiovascular Magnetic Resonance, Fondazione CNR/Regione Toscana 
      Gabriele Monasterio, Via Moruzzi 1, 56124 Pisa, Italy. gnucifora@cardionet.it
FAU - Aquaro, Giovanni D
AU  - Aquaro GD
FAU - Pingitore, Alessandro
AU  - Pingitore A
FAU - Masci, Pier Giorgio
AU  - Masci PG
FAU - Lombardi, Massimo
AU  - Lombardi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110104
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Eur J Heart Fail. 2011 Feb;13(2):127-9. PMID: 21262927
CIN - Eur J Heart Fail. 2011 May;13(5):577-8. PMID: 21459890
CIN - Eur J Heart Fail. 2011 Oct;13(10):1153-4; author reply 1154. PMID: 21873338
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Cardiomyopathies/*diagnosis/epidemiology
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Disease Progression
MH  - Female
MH  - Fibrosis/pathology
MH  - Gadolinium
MH  - Humans
MH  - Incidence
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Radiographic Image Enhancement/methods
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stroke Volume/physiology
MH  - Ventricular Dysfunction, Left/*diagnosis/epidemiology
MH  - Young Adult
EDAT- 2011/01/07 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - hfq222 [pii]
AID - 10.1093/eurjhf/hfq222 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2011 Feb;13(2):170-6. doi: 10.1093/eurjhf/hfq222. Epub 2011 Jan 
      4.