PMID- 21209833
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 12
DP  - 2010 Dec 31
TI  - SNPs in the FCER1A gene region show no association with allergic rhinitis in a 
      Han Chinese population.
PG  - e15792
LID - 10.1371/journal.pone.0015792 [doi]
LID - e15792
AB  - BACKGROUND: Immunoglobulin E (IgE) is a central player in the allergic response, 
      and raised total IgE levels are considered as an indicator of atopy or potential 
      development of atopy. A recent genome-wide scan in a German population-based 
      cohort of adults identified the gene encoding the alpha chain of the high 
      affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total 
      serum IgE levels. The aim of this study was to investigate whether the 
      polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a 
      Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: A population of 378 
      patients with AR and 288 healthy controls was studied. Precise phenotyping of 
      patients was accomplished by means of a questionnaire and clinical examination. 
      Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) 
      measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were 
      selected and individually genotyped. None of the SNPs in the FCER1A showed an 
      association with AR. Similarly, the lack of association was also evident in 
      subgroup analysis for the presence of different allergen sensitivities. None of 
      the selected SNPs in FCER1A was associated with total IgE level. CONCLUSIONS: 
      Although FCER1A presents itself as a good candidate for contributing to total 
      serum IgE, this study failed to find an association between SNPs in the FCER1A 
      gene region and IgE level or AR susceptibility.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education of 
      China, Beijing Institute of Otorhinolaryngology, Beijing, People's Republic of 
      China.
FAU - Duan, Su
AU  - Duan S
FAU - Lin, Xiaoping
AU  - Lin X
FAU - Zhang, Wei
AU  - Zhang W
FAU - Meng, Na
AU  - Meng N
FAU - Zhao, Liping
AU  - Zhao L
FAU - Zhao, Yan
AU  - Zhao Y
FAU - Han, Demin
AU  - Han D
FAU - Zhang, Luo
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101231
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (FCER1A protein, human)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/immunology/metabolism
MH  - Male
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, IgE/*genetics
MH  - Rhinitis, Allergic, Perennial/*ethnology/*genetics
MH  - Sequence Analysis, DNA
PMC - PMC3013135
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/01/07 06:00
MHDA- 2011/07/06 06:00
PMCR- 2010/12/31
CRDT- 2011/01/07 06:00
PHST- 2010/08/17 00:00 [received]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
PHST- 2010/12/31 00:00 [pmc-release]
AID - PONE-D-10-00743 [pii]
AID - 10.1371/journal.pone.0015792 [doi]
PST - epublish
SO  - PLoS One. 2010 Dec 31;5(12):e15792. doi: 10.1371/journal.pone.0015792.