PMID- 2121010
OWN - NLM
STAT- MEDLINE
DCOM- 19901105
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 120
IP  - 4
DP  - 1990 Oct
TI  - Myocardial infarct size reduction by the synergistic effect of hyperbaric oxygen 
      and recombinant tissue plasminogen activator.
PG  - 791-800
AB  - Fasting mongrel dogs underwent hyperbaric oxygen treatment (HBOT), recombinant 
      tissue plasminogen activator (rt-PA) treatment, and simultaneous HBOT and rt-PA 
      treatment following prior experimental left anterior descending coronary artery 
      occlusion for 2 hours. Thrombosis in and around a copper coil was recorded 
      angiographically at regular intervals, and immediately prior to treatment 
      conclusion. Controls (n = 10) were untreated. Group two animals (n = 10) were 
      treated additionally with 90 minutes of HBOT at 2 atm absolute. Group three 
      animals (n = 8) were treated additionally with 50 mg rt-PA over 90 minutes. Group 
      four animals (n = 10) were treated additionally with simultaneous HBOT and rt-PA 
      over 90 minutes. Myocardial injury was determined by a combination of 
      triphenyltetrazolium chloride histochemical staining and by formazan dye 
      extraction. Damage was measured as a percent of left ventricular cross-sectional 
      area studied. HBOT alone restored 35.9% of oxidative enzyme activity (p greater 
      than 0.001). Treatment with rt-PA alone restored 48.9% of enzyme activity (p 
      greater than 0.001). The combination of HBOT and simultaneous rt-PA resulted in 
      96.9% restoration of oxidative enzyme activity versus the control group (p 
      greater than 0.001).
FAU - Thomas, M P
AU  - Thomas MP
AD  - Department of Surgery and Pathology, Meridia Huron Hospital, Cleveland, OH 44112.
FAU - Brown, L A
AU  - Brown LA
FAU - Sponseller, D R
AU  - Sponseller DR
FAU - Williamson, S E
AU  - Williamson SE
FAU - Diaz, J A
AU  - Diaz JA
FAU - Guyton, D P
AU  - Guyton DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Animals
MH  - Combined Modality Therapy
MH  - Dogs
MH  - Female
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Myocardial Infarction/drug therapy/pathology/*therapy
MH  - Myocardium/enzymology/pathology
MH  - Recombinant Proteins/therapeutic use
MH  - Tissue Plasminogen Activator/*therapeutic use
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 0002-8703(90)90194-3 [pii]
AID - 10.1016/0002-8703(90)90194-3 [doi]
PST - ppublish
SO  - Am Heart J. 1990 Oct;120(4):791-800. doi: 10.1016/0002-8703(90)90194-3.