PMID- 21210846
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20131121
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Apr
TI  - Protective effect of antioxidants on blood oxidative stress caused by arginine.
PG  - 250-8
LID - 10.1111/j.1472-8206.2010.00909.x [doi]
AB  - In this study, we investigated in vivo and in vitro effect of arginine on 
      parameters of oxidative stress namely thiobarbituric acid-reactive substances 
      (TBA-RS) and total radical-trapping antioxidant parameter (TRAP) in plasma and on 
      the antioxidant enzymes activities catalase (CAT), glutathione peroxidase 
      (GSH-Px), and superoxide dismutase (SOD) in erythrocytes of rats. Results showed 
      that acute administration reduced TRAP and CAT activity and increased TBA-RS. 
      Furthermore, in vitro studies did not alter oxidative parameters studied. The 
      influence of N(omega)-nitro-L-arginine methyl ester (L-NAME) and antioxidants 
      (alpha-tocopherol plus ascorbic acid) on the effects elicited by arginine was also 
      studied. In addition, simultaneous injection of L-NAME or treatment with 
      antioxidants prevented the alteration on TRAP, TBA-RS, and CAT activity caused by 
      arginine. Data indicate that oxidative stress induction is probably mediated by 
      the generation of NO and/or ONOO(-) and other free radicals, because L-NAME and 
      these antioxidants prevented these effects caused by arginine.
CI  - (c) 2011 The Authors Fundamental and Clinical Pharmacology (c) 2011 Societe Francaise 
      de Pharmacologie et de Therapeutique.
FAU - de Lima, Daniela Delwing
AU  - de Lima DD
AD  - Departamento de Medicina, Universidade da Regiao de Joinville- UNIVILLE, Campus 
      Universitario, Bairro Bom Retiro, CEP 89201-972, Joinville, SC, Brazil.
FAU - Delwing, Fabio
AU  - Delwing F
FAU - da Cruz, Jose Geraldo Pereira
AU  - da Cruz JG
FAU - Wyse, Angela Terezinha Souza
AU  - Wyse AT
FAU - Delwing-Dal Magro, Debora
AU  - Delwing-Dal Magro D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110107
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 0 (Antioxidants)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - H4N855PNZ1 (alpha-Tocopherol)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/*pharmacology
MH  - Arginine/*toxicity
MH  - Ascorbic Acid/administration & dosage/pharmacology
MH  - Catalase/metabolism
MH  - Erythrocytes/metabolism
MH  - Free Radical Scavengers/pharmacology
MH  - Glutathione Peroxidase/metabolism
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/*metabolism
MH  - alpha-Tocopherol/administration & dosage/pharmacology
EDAT- 2011/01/08 06:00
MHDA- 2012/07/10 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - 10.1111/j.1472-8206.2010.00909.x [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2012 Apr;26(2):250-8. doi: 
      10.1111/j.1472-8206.2010.00909.x. Epub 2011 Jan 7.