PMID- 2121102
OWN - NLM
STAT- MEDLINE
DCOM- 19901119
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 17
IP  - 10
DP  - 1990 Oct
TI  - [Hepatic resection plus hepatic artery infusion with implantable port for 
      colorectal metastases].
PG  - 2071-5
AB  - Hepatic resection of metastatic colorectal carcinoma offers a chance for long 
      term survival and is being performed with increasing frequency. The aim of this 
      study is to reduce the re relapse in the residual liver after curative 
      hepatectomy. Nineteen patients with hepatic metastases from colorectal carcinoma 
      who underwent hepatic resection plus hepatic artery infusion therapy using an 
      implantable port (HR-HAI) were analyzed. As hepatic resection, lobectomies were 
      performed in 6 patients, segmentectomies in 8 patients and wedge resection in 5 
      patients. As chemotherapeutic agents, adriamycin in 8 patients, mitomycin C in 7 
      patients and OK-432 in 4 patients were used. The drugs were administered through 
      hepatic artery via a port every one month for one year at the out patient clinic. 
      Eight out of 19 patients had no complication by HR-HAI therapy, but 3 patients 
      had catheter obstruction within one year, 4 had gastrointestinal discomfort, 3 
      fever up and 1 liver tissue necrosis. The serious hepatotoxicity such as 
      sclerosing cholangitis was not observed. Re-relapses were appeared in 15 patients 
      and the sites were the residual liver in 10 patients, and 5 in the other organs. 
      The 3-year survival rate of 19 treated patients was 40.0% higher than 33.3% of 52 
      patients undergone hepatic resection alone, but the difference was not 
      statistically significant.
FAU - Kikkawa, N
AU  - Kikkawa N
AD  - Dept. of Surgery, Osaka National Hospital.
FAU - Tsuchiya, Y
AU  - Tsuchiya Y
FAU - Kawahara, T
AU  - Kawahara T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Mitomycins)
RN  - 39325-01-4 (Picibanil)
RN  - 50SG953SK6 (Mitomycin)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antineoplastic Agents/*administration & dosage/therapeutic use
MH  - Colorectal Neoplasms/*pathology
MH  - Combined Modality Therapy
MH  - Doxorubicin/administration & dosage/therapeutic use
MH  - Female
MH  - *Hepatectomy
MH  - Hepatic Artery
MH  - Humans
MH  - *Infusion Pumps, Implantable
MH  - Infusions, Intra-Arterial/methods
MH  - Liver Neoplasms/mortality/secondary/*therapy
MH  - Middle Aged
MH  - Mitomycin
MH  - Mitomycins/administration & dosage/therapeutic use
MH  - Picibanil/administration & dosage/therapeutic use
MH  - Survival Rate
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1990 Oct;17(10):2071-5.