PMID- 21211361
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 49
IP  - 12
DP  - 2010 Dec
TI  - [Clinical characteristics of acute graft-versus-host disease confined solely to 
      gastrointestinal tract after allogeneic hematopoietic stem cell transplantation].
PG  - 1028-31
AB  - OBJECTIVE: To observe the characteristics of acute graft-versus-host disease 
      (aGVHD) confined solely to gastrointestinal tract after allogeneic hematopoietic 
      stem cell transplantation (allo-HSCT). METHODS: Clinical data of 307 patients who 
      received allo-HSCT in our hospital between November 2007 and December 2008 were 
      retrospectively analyzed. Clinical features, risk factors, therapeutic effects 
      and prognosis of 38 patients whose aGVHD confined solely to gastrointestinal 
      tract after allo-HSCT were analyzed. RESULTS: The incidence of aGVHD was 56.7% 
      (174/307). aGVHD confined solely to gastrointestinal tract occurred in 38 out of 
      174 patients (21.8%). The incidence of aGVHD confined solely to gastrointestinal 
      tract was affected by human leukocyte antigen (HLA)-compatible level. The 
      patients transplanted from HLA-matched donor had a higher probability of aGVHD 
      confined solely to the gastrointestinal tract. After treatment with 
      glucocorticoids or anti-CD(25) monoclonal antibody, 2 patients who had aGVHD 
      confined solely to the gastrointestinal tract died of uncontrolled aGVHD and 
      concurrent infection. The total effective rate was 94.7%. But for patients who 
      had aGVHD between II-IV degree and not confined solely to gastrointestinal, 
      therapeutic effective rate was 85.2%. There was a difference in therapeutic 
      effect between the two groups (P = 0.015). Anti-CD(25) monoclonal antibody was 
      used in 12 patients who had aGVHD confined solely to the gastrointestinal tract 
      and all patients' conditions of aGVHD were controlled. CONCLUSIONS: aGVHD 
      confined solely to gastrointestinal tract after HSCT was not rare. The incidence 
      of aGVHD confined solely to gastrointestinal tract was higher in HLA-matched 
      sibling donor than in mismatched transplantation. Therapeutic efficacy for the 
      aGVHD confined solely to gastrointestinal tract was good. The favorable outcome 
      might be related with the application of anti-CD(25) monoclonal antibody.
FAU - Feng, Ru
AU  - Feng R
AD  - Institute of Hematology, People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Liu, Dai-hong
AU  - Liu DH
FAU - Xu, Lan-ping
AU  - Xu LP
FAU - Chen, Huan
AU  - Chen H
FAU - Zhang, Xiao-hui
AU  - Zhang XH
FAU - Han, Wei
AU  - Han W
FAU - Zhao, Ting
AU  - Zhao T
FAU - Liu, Kai-yan
AU  - Liu KY
FAU - Huang, Xiao-jun
AU  - Huang XJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Gastrointestinal Diseases/diagnosis/*etiology/pathology
MH  - Graft vs Host Disease/*diagnosis/therapy
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Transplantation, Homologous/adverse effects
MH  - Young Adult
EDAT- 2011/01/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2010 Dec;49(12):1028-31.