PMID- 21214522
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110517
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Feb
TI  - HLA-DR4 antigen and idiopathic dilated cardiomyopathy susceptibility: a 
      meta-analysis involving 11,761 subjects.
PG  - 107-11
LID - 10.1111/j.1399-0039.2010.01589.x [doi]
AB  - Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial 
      disorder initiated by an environment trigger in individuals with predisposing 
      human leukocyte antigen (HLA) alleles. Published data on the association between 
      HLA-DR4 antigen and IDC risk are inconclusive. To derive a more precise 
      estimation of the relationship, a meta-analysis was performed. Studies in 
      English-language articles were identified by a search of PubMed and Embase 
      database (inception to June 2010). A total of 19 case-control studies including 
      1378 cases and 10,383 controls provided data on the association between HLA-DR4 
      antigen and genetic susceptibility to IDC. Overall, statistically elevated 
      frequency of HLA-DR4 allele [OR (odds ratio), 1.58; 95% CI (confidence interval), 
      1.21-2.07; P = 0.0009] was found in patients with IDC compared with controls. 
      When stratified by myocardial biopsy or non-biopsy cases, statistically increased 
      risks were found for IDC in both subgroups. In the subgroup analysis by 
      ethnicity, significantly increased risk was found among Europeans from 12 
      case-control studies (OR, 1.54; 95% CI, 1.11-2.12; P = 0.009). In conclusion, our 
      results suggest that HLA-DR4 antigen is a low-penetrant risk factor for 
      developing IDC in Europeans.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Jin, B
AU  - Jin B
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Ni, H
AU  - Ni H
FAU - Geshang, Q
AU  - Geshang Q
FAU - Li, Y
AU  - Li Y
FAU - Shen, W
AU  - Shen W
FAU - Shi, H
AU  - Shi H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
EIN - Tissue Antigens. 2011 Apr;77(4):365
MH  - Cardiomyopathy, Dilated/*genetics/immunology
MH  - Case-Control Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR4 Antigen/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Risk Factors
EDAT- 2011/01/11 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1111/j.1399-0039.2010.01589.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Feb;77(2):107-11. doi: 10.1111/j.1399-0039.2010.01589.x.