PMID- 21214525
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Feb
TI  - Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with 
      recurrent spontaneous abortions.
PG  - 131-5
LID - 10.1111/j.1399-0039.2010.01584.x [doi]
AB  - Human leukocyte antigen (HLA)-G is predominantly expressed on the extravillous 
      cytotrophoblasts at the fetal-maternal interface. The 14-bp polymorphism in exon 
      8 is associated with HLA-G messenger ribonucleic acid (mRNA) stability and 
      isoform alternative splicing patterns, thereby influencing the functionality of 
      HLA-G in pregnancy. We analysed the 14-bp indel polymorphism in 143 recurrent 
      spontaneous abortions (RSAs) and 150 control couples. We did not find any 
      significant difference in the 14-bp insertion/deletion allele frequencies among 
      the RSA and control couples. Analysis for increased sharing of the polymorphism 
      in the RSA and the control couples also did not show any significant difference. 
      However, we found an increase in the frequency of the 14-bp deletion homozygotes 
      in the RSA women, which could lead to extremely high levels of soluble HLA-G 
      (sHLA-G).
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Aruna, M
AU  - Aruna M
AD  - Molecular Anthropology Group, Biological Anthropology Unit, Indian Statistical 
      Institute, Habsiguda, Hyderabad, India.
FAU - Sirisha, P V S
AU  - Sirisha PV
FAU - Andal Bhaskar, S
AU  - Andal Bhaskar S
FAU - Tarakeswari, S
AU  - Tarakeswari S
FAU - Thangaraj, K
AU  - Thangaraj K
FAU - Reddy, B M
AU  - Reddy BM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
EIN - Tissue Antigens. 2011 Apr;77(4):365
MH  - Abortion, Habitual/diagnosis/*genetics/immunology
MH  - Abortion, Spontaneous/diagnosis/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Homozygote
MH  - Humans
MH  - Polymorphism, Genetic/*genetics
MH  - Pregnancy
MH  - *Sequence Deletion
EDAT- 2011/01/11 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1111/j.1399-0039.2010.01584.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Feb;77(2):131-5. doi: 10.1111/j.1399-0039.2010.01584.x.