PMID- 21214635
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20110919
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 25
IP  - 10
DP  - 2011 Oct
TI  - Clinical features of atopic dermatitis in a hospital-based setting in China.
PG  - 1206-12
LID - 10.1111/j.1468-3083.2010.03953.x [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin 
      disease. There have been few detailed reports of the clinical evaluation of 
      Chinese patients with AD. OBJECTIVES: To give a profile of the clinical features 
      of Chinese AD patients in a university hospital setting. METHODS: A total of 1008 
      cases met Hanifin and Rajka diagnostic criteria of AD were recruited at Xinhua 
      Hospital, Shanghai Jiaotong University School of Medicine, China. RESULTS: In our 
      survey, 22.7% patients were mild, 66.6% were moderate and 10.7% were severe 
      according to the SCORAD index. Both the frequency and severity of the male 
      patients were slightly higher. The frequency of asthma among the AD patients was 
      16.7% and it was increased with the age (chi2 = 205.20, P = 0.000). The frequencies 
      of objective minor signs were demonstrated with age-related changes. Besides, 
      three localized variants including eyelid eczema (49.8%), scalp dermatitis 
      (49.7%), infra-auricular and retroauricular fissuring (44.8%) were commonly 
      observed, especially in the infantile phase (P < 0.01). It was showed significant 
      differences in serum total immunoglobulin E (IgE) and eosinophil cationic protein 
      (ECP) levels of different age groups. The positive rate of Phadiatop was raised 
      after 3 years old and that of the common food allergens were decreased after 6 
      years old. CONCLUSIONS: More males than females had ongoing AD in our survey. 
      Most AD debuted in the first year of the cases. High incidence of the three 
      clinical signs: eyelid eczema, scalp dermatitis and infra-auricular and 
      retroauricular fissuring among the patients suggests it can be a potential 
      valuable diagnostic clue to AD.
CI  - (c) 2011 The Authors. Journal of the European Academy of Dermatology and 
      Venereology (c) 2011 European Academy of Dermatology and Venereology.
FAU - Shi, M
AU  - Shi M
AD  - Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School 
      of Medicine, Shanghai, China.
FAU - Zhang, H
AU  - Zhang H
FAU - Chen, X
AU  - Chen X
FAU - Guo, Y
AU  - Guo Y
FAU - Tao, J
AU  - Tao J
FAU - Qi, H
AU  - Qi H
FAU - Gan, J
AU  - Gan J
FAU - Jiang, A
AU  - Jiang A
FAU - Yu, H
AU  - Yu H
FAU - Liang, J
AU  - Liang J
FAU - Chen, J
AU  - Chen J
FAU - Yang, L
AU  - Yang L
FAU - Zhuang, Y
AU  - Zhuang Y
FAU - Yan, M
AU  - Yan M
FAU - Gu, Y
AU  - Gu Y
FAU - Yu, X
AU  - Yu X
FAU - Feng, X
AU  - Feng X
FAU - Yao, Z
AU  - Yao Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110109
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asthma/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Comorbidity
MH  - Dermatitis, Atopic/*blood/epidemiology/*pathology
MH  - Eosinophil Cationic Protein/blood
MH  - Female
MH  - Health Surveys
MH  - *Hospitals, University
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Severity of Illness Index
MH  - Skin/pathology
MH  - Socioeconomic Factors
MH  - Young Adult
EDAT- 2011/01/11 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1111/j.1468-3083.2010.03953.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1206-12. doi: 
      10.1111/j.1468-3083.2010.03953.x. Epub 2011 Jan 9.