PMID- 21215612
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20131121
IS  - 1873-2976 (Electronic)
IS  - 0960-8524 (Linking)
VI  - 102
IP  - 5
DP  - 2011 Mar
TI  - Generalised additive modelling approach to the fermentation process of glutamate.
PG  - 4184-90
LID - 10.1016/j.biortech.2010.12.026 [doi]
AB  - In this work, generalised additive models (GAMs) were used for the first time to 
      model the fermentation of glutamate (Glu). It was found that three fermentation 
      parameters fermentation time (T), dissolved oxygen (DO) and oxygen uptake rate 
      (OUR) could capture 97% variance of the production of Glu during the fermentation 
      process through a GAM model calibrated using online data from 15 fermentation 
      experiments. This model was applied to investigate the individual and combined 
      effects of T, DO and OUR on the production of Glu. The conditions to optimize the 
      fermentation process were proposed based on the simulation study from this model. 
      Results suggested that the production of Glu can reach a high level by 
      controlling concentration levels of DO and OUR to the proposed optimization 
      conditions during the fermentation process. The GAM approach therefore provides 
      an alternative way to model and optimize the fermentation process of Glu.
CI  - Crown Copyright (c) 2010. Published by Elsevier Ltd. All rights reserved.
FAU - Liu, Chun-Bo
AU  - Liu CB
AD  - Key Laboratory of Advanced Process Control for Light Industry, Ministry of 
      Education, Jiangnan University, Wuxi 214122, PR China.
FAU - Li, Yun
AU  - Li Y
FAU - Pan, Feng
AU  - Pan F
FAU - Shi, Zhong-Ping
AU  - Shi ZP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101215
PL  - England
TA  - Bioresour Technol
JT  - Bioresource technology
JID - 9889523
RN  - 3KX376GY7L (Glutamic Acid)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Computer Simulation
MH  - Corynebacterium glutamicum/metabolism/*physiology
MH  - Fermentation/*physiology
MH  - Glutamic Acid/*biosynthesis
MH  - Linear Models
MH  - Oxygen/metabolism
MH  - Time Factors
EDAT- 2011/01/11 06:00
MHDA- 2011/05/21 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2010/12/03 00:00 [revised]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - S0960-8524(10)01956-5 [pii]
AID - 10.1016/j.biortech.2010.12.026 [doi]
PST - ppublish
SO  - Bioresour Technol. 2011 Mar;102(5):4184-90. doi: 10.1016/j.biortech.2010.12.026. 
      Epub 2010 Dec 15.