PMID- 21216465
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20220321
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 35
IP  - 8
DP  - 2011 Aug
TI  - Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic 
      cells.
PG  - 1093-101
LID - 10.1016/j.leukres.2010.12.011 [doi]
AB  - In search for compounds able to reduce cell adhesion-mediated drug resistance 
      (CAM-DR), we studied effects of Hammada scoparia extracts on leukemic cells 
      adherent or in suspension. We show that H. scoparia flavonoidic fraction and its 
      compound rutin induce apoptosis specifically in adherent leukemic cells and 
      abolish CAM-DR. Importantly, rutin inhibited survival of adherent leukemic 
      progenitors (CD34(+)38(-)123(+)) but spared normal progenitors (CD34(+)38(-)). 
      The pro-apoptotic effects of rutin were correlated with a decrease of active 
      GSK3beta and inhibitors of GSK3beta reproduced rutin-induced cytotoxicity. This study 
      uncovers the potential of H. scoparia flavonoids and rutin to overcome CAM-DR in 
      acute myeloid leukemia.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Bourogaa, Ezzeddine
AU  - Bourogaa E
AD  - Laboratoire de Chimie des Substances Naturelles, Sfax, Tunisia.
FAU - Bertrand, Jessica
AU  - Bertrand J
FAU - Despeaux, Mathieu
AU  - Despeaux M
FAU - Jarraya, Raoudha
AU  - Jarraya R
FAU - Fabre, Nicolas
AU  - Fabre N
FAU - Payrastre, Laurence
AU  - Payrastre L
FAU - Demur, Cecile
AU  - Demur C
FAU - Fournie, Jean-Jacques
AU  - Fournie JJ
FAU - Damak, Mohamed
AU  - Damak M
FAU - Feki, Abdelfattah El
AU  - Feki AE
FAU - Racaud-Sultan, Claire
AU  - Racaud-Sultan C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110108
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Antigens, CD34)
RN  - 0 (Flavonoids)
RN  - 5G06TVY3R7 (Rutin)
RN  - EC 2.7.11.1 (GSK3B protein, human)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Antigens, CD34/metabolism
MH  - Apoptosis/*drug effects
MH  - Blotting, Western
MH  - Cell Adhesion/*drug effects
MH  - Cells, Cultured
MH  - Drug Resistance, Neoplasm/*drug effects
MH  - Flavonoids/pharmacology
MH  - Flow Cytometry
MH  - Glycogen Synthase Kinase 3/antagonists & inhibitors/metabolism
MH  - Glycogen Synthase Kinase 3 beta
MH  - Hematopoietic Stem Cells/drug effects/metabolism
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*drug therapy/*pathology
MH  - *Phytotherapy
MH  - Rutin/*pharmacology
MH  - Scoparia/*chemistry
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
EDAT- 2011/01/11 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/10/30 00:00 [received]
PHST- 2010/12/13 00:00 [revised]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0145-2126(10)00607-7 [pii]
AID - 10.1016/j.leukres.2010.12.011 [doi]
PST - ppublish
SO  - Leuk Res. 2011 Aug;35(8):1093-101. doi: 10.1016/j.leukres.2010.12.011. Epub 2011 
      Jan 8.