PMID- 21217043
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20190522
IS  - 1943-4936 (Electronic)
IS  - 1040-6387 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Jan
TI  - Pathological and immunohistochemical features of subdural histiocytic sarcomas in 
      15 dogs.
PG  - 127-32
AB  - Subdural histiocytic sarcomas from 15 dogs (mean age 7.8 years) were 
      histopathologically examined. Among the 15 dogs, there was a marked breed 
      predominance (toward Pembroke Welsh Corgi dogs, 47%), but no gender predilection. 
      Focal solitary subdural masses were detected in the cerebrum (12 cases) and 
      spinal cord (1 case), whereas diffuse infiltrative lesions were observed in the 
      cerebral leptomeninges in 2 cases. All neoplastic lesions had common histological 
      features characterized by the proliferation of pleomorphic histiocytic cells 
      combined with various inflammatory reactions. Multinucleated giant cells, 
      phagocytosis, and atypical mitotic figures in the neoplastic cells were commonly 
      observed. Most of the pleomorphic neoplastic cells in the present cases were 
      immunopositive for monocytic, histiocytic, or both markers, such as human 
      leukocyte antigen (HLA)-DR, ionized calcium-binding adaptor molecule 1 (Iba1), 
      cluster of differentiation (CD)163, and CD204, except for the neoplastic cells in 
      2 focal and 2 diffuse histiocytic sarcomas. The findings suggest that differences 
      in cell origin, molecular expression, or both patterns are responsible for the 
      distribution patterns of canine subdural histiocytic sarcomas.
FAU - Ide, Tetsuya
AU  - Ide T
AD  - Department of Veterinary Pathology, Graduate School of Agricultural and Life 
      Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
FAU - Uchida, Kazuyuki
AU  - Uchida K
FAU - Kagawa, Yumiko
AU  - Kagawa Y
FAU - Suzuki, Kazuhiko
AU  - Suzuki K
FAU - Nakayama, Hiroyuki
AU  - Nakayama H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/metabolism/pathology/*veterinary
MH  - Dog Diseases/metabolism/*pathology
MH  - Dogs
MH  - Female
MH  - Histiocytic Sarcoma/metabolism/pathology/*veterinary
MH  - Immunohistochemistry/veterinary
MH  - Male
MH  - Subdural Space
EDAT- 2011/01/11 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 23/1/127 [pii]
AID - 10.1177/104063871102300123 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2011 Jan;23(1):127-32. doi: 10.1177/104063871102300123.