PMID- 21217128
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20211020
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 66
IP  - 3
DP  - 2011 Mar
TI  - Retrospective evidence for a biological cost of vancomycin resistance 
      determinants in the absence of glycopeptide selective pressures.
PG  - 608-10
LID - 10.1093/jac/dkq512 [doi]
AB  - OBJECTIVES: To estimate the relative fitness differences between 
      glycopeptide-resistant Enterococcus faecium (GREF) and glycopeptide-susceptible 
      E. faecium (GSEF) from yearly surveillance data on the occurrence of GREF in 
      Danish poultry farm environments. METHODS: A population genetic model was adapted 
      to retrospectively estimate the biological fitness cost of acquired resistance. 
      Maximization of a likelihood function was used to predict the longitudinal 
      persistence of acquired resistance. RESULTS: Our analysis suggests strong 
      selection against GREF following the 1995 ban on the glycopeptide growth promoter 
      avoparcin. However, parameterizing the model with two selection coefficients 
      suggesting a reduced negative effect of the acquired resistance on bacterial 
      fitness over time significantly improved the fit of the model. Our analyses 
      suggest that the acquired glycopeptide resistance will persist for >25 years. 
      CONCLUSIONS: Acquired resistance determinants in commensal E. faecium populations 
      in Danish farm environments are likely to persist for decades, even in the 
      absence of glycopeptide use.
FAU - Johnsen, P J
AU  - Johnsen PJ
AD  - Department of Pharmacy, Faculty of Health Sciences, University of Tromso, 9037 
      Tromso, Norway. paal.johnsen@uit.no
FAU - Townsend, J P
AU  - Townsend JP
FAU - Bohn, T
AU  - Bohn T
FAU - Simonsen, G S
AU  - Simonsen GS
FAU - Sundsfjord, A
AU  - Sundsfjord A
FAU - Nielsen, K M
AU  - Nielsen KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110107
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glycopeptides)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - Carrier State/microbiology/*veterinary
MH  - Denmark
MH  - Enterococcus faecium/*growth & development
MH  - Glycopeptides/pharmacology
MH  - Gram-Positive Bacterial Infections/microbiology/*veterinary
MH  - Poultry/microbiology
MH  - *Vancomycin Resistance
PMC - PMC3037156
EDAT- 2011/01/11 06:00
MHDA- 2011/07/16 06:00
PMCR- 2011/01/07
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
PHST- 2011/01/07 00:00 [pmc-release]
AID - dkq512 [pii]
AID - 10.1093/jac/dkq512 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2011 Mar;66(3):608-10. doi: 10.1093/jac/dkq512. Epub 2011 
      Jan 7.