PMID- 21217921
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Print)
IS  - 2092-7355 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Jan
TI  - Biomarkers predicting isocyanate-induced asthma.
PG  - 21-6
LID - 10.4168/aair.2011.3.1.21 [doi]
AB  - THREE DIISOCYANATES CAN CAUSE OCCUPATIONAL ASTHMA (OA): toluene diisocyanate 
      (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate 
      (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on 
      investigated immunologic, genetic, neurogenic, and protein markers, because there 
      is no serological testing method. The prevalence of serum IgG to cytokeratin 
      (CK)18 and CK19 in TDI-OA was significantly higher than in controls, although the 
      prevalence of these antibodies was too low for them to be used as biomarkers. 
      Another candidate biomarker was serum IgG to tissue transglutaminase (tTG), 
      because the prevalence of serum specific IgG to tTG was significantly higher in 
      patients with TDI-OA than in controls. The human leukocyte antigen (HLA) 
      DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be used as a genetic marker for 
      TDI-OA in Koreans via enhanced specific IgE sensitization in exposed subjects. 
      The genetic polymorphisms of catenin alpha 3, alpha-T catenin (CTNNA3) were 
      significantly associated with TDI-OA. Additionally, examining the neurokinin 2 
      receptor (NK2R) 7853G>A and 11424 G>A polymorphisms, the NK2R 7853GG genotype had 
      higher serum vascular endothelial growth factor (VEGF) levels than the GA or AA 
      genotypes among Korean workers exposed to TDI. To identify new serologic markers 
      using a proteomic approach, differentially expressed proteins between subjects 
      with MDI-OA and asymptomatic exposed controls in a Korean population showed that 
      the optimal serum cutoff levels were 69.8 ng/mL for ferritin and 2.5 microg/mL for 
      transferrin. When these two parameters were combined, the sensitivity was 71.4% 
      and the specificity was 85.7%. The serum cytokine matrix metalloproteinase-9 
      (MMP-9) level is a useful biomarker for identifying cases of TDI-OA among exposed 
      workers. Despite these possible biomarkers, more effort should be focused on 
      developing early diagnostic biomarkers using a comprehensive approach based on 
      the pathogenic mechanisms of isocyanate-induced OA.
FAU - Palikhe, Nami Shrestha
AU  - Palikhe NS
AD  - Department of Allergy & Rheumatology, Ajou University School of Medicine, Suwon, 
      Korea.
FAU - Kim, Joo-Hee
AU  - Kim JH
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC3005314
OTO - NOTNLM
OT  - 4,4-diphenylmethane diisocyanate
OT  - Isocyanate
OT  - biomarkers
OT  - occupational asthma
OT  - toluene diisocyanate
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2011/01/11 06:00
MHDA- 2011/01/11 06:01
PMCR- 2011/01/01
CRDT- 2011/01/11 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/01/11 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.4168/aair.2011.3.1.21 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2011 Jan;3(1):21-6. doi: 10.4168/aair.2011.3.1.21. 
      Epub 2010 Jul 29.