PMID- 21219175
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20220311
IS  - 1545-3278 (Electronic)
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 29
DP  - 2011
TI  - HLA/KIR restraint of HIV: surviving the fittest.
PG  - 295-317
LID - 10.1146/annurev-immunol-031210-101332 [doi]
AB  - Multiple epidemiological studies have demonstrated associations between the human 
      leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and 
      more recently the killer cell immunoglobulin-like (KIR) locus has been implicated 
      in differential responses to the virus. Genome-wide association studies have 
      convincingly shown that the HLA class I locus is the most significant host 
      genetic contributor to the variation in HIV control, underscoring a central role 
      for CD8 T cells in resistance to the virus. However, both genetic and functional 
      data indicate that part of the HLA effect on HIV is due to interactions between 
      KIR and HLA genes, also implicating natural killer cells in defense against viral 
      infection and viral expansion prior to initiation of an adaptive response. We 
      review the HLA and KIR associations with HIV disease and the progress that has 
      been made in understanding the mechanisms that explain these associations.
FAU - Bashirova, Arman A
AU  - Bashirova AA
AD  - Ragon Institute of Massachusetts General Hospital, MIT, Boston, Massachusetts 
      02129, USA. Arman.Bashirova@nih.gov
FAU - Thomas, Rasmi
AU  - Thomas R
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Animals
MH  - HIV Infections/*immunology
MH  - *HIV-1
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Receptors, KIR/*immunology
MH  - T-Lymphocytes/immunology
PMC - PMC3725604
MID - NIHMS493589
EDAT- 2011/01/12 06:00
MHDA- 2011/06/09 06:00
PMCR- 2013/07/29
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
PHST- 2013/07/29 00:00 [pmc-release]
AID - 10.1146/annurev-immunol-031210-101332 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2011;29:295-317. doi: 10.1146/annurev-immunol-031210-101332.