PMID- 21219698
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20190513
IS  - 1945-2403 (Electronic)
IS  - 0146-4760 (Linking)
VI  - 35
IP  - 1
DP  - 2011 Jan
TI  - Differences in binding affinities of MDA, MDMA, MDEA, Amphetamine, 
      Methamphetamine, and their deuterated analogues to solid-phase extraction 
      cartridges.
PG  - 15-22
AB  - This study evaluated the potential for partial separation of drugs from their 
      deuterated internal standards using Cerex((R)) Polycrom CLIN II solid-phase 
      extraction (SPE) cartridges. After elution from the column and derivatization, 
      gas chromatography-mass spectrometry results showed that the target compound 
      eluted from the SPE cartridge prior to its deuterated form. This elution 
      separation effect was greater for 3,4-methylenedioxymethamphetamine (MDMA) and 
      methamphetamine (MAMP) than for the other drugs studied. When the drugs were 
      eluted in 0.5 mL increments from a 50 mg sorbent bed, no drug appeared in the 
      first fraction. The drug to internal standard ratios (expected value 1.00) for 
      subsequent fractions collected were 1.30, 1.07, and 0.83 for MDA/MDA-d(5); 1.65, 
      1.18, 0.67, and 0.56 for MDMA/MDMAd(5); and 1.37, 1.18, and 0.95 for 
      MDEA/MDEA-d(6). For d-AMP and d-MAMP, the expected ratio was 0.40. The subsequent 
      ratios were 0.63, 0.46, 0.35, and 0.34 for d-AMP/d-AMP-d(11); and 1.00, 0.59, 
      0.25, and 0.18 for d-MAMP/d-MAMP-d(14). The affinity of d-MAMPd(14) was shown to 
      be greater than that of d-MAMP-d(5), and deuteration at the propyl end of the 
      molecule was shown to increase binding more than deuteration on the phenyl group.
FAU - Romberg, R W
AU  - Romberg RW
AD  - Navy Drug Screening Laboratory, 320B B Street, Great Lakes, Illinois, USA. 
      robert.romberg@med.navy.mil
FAU - Ntamack, A G
AU  - Ntamack AG
FAU - Blacik, L J
AU  - Blacik LJ
FAU - Kazarian, C M
AU  - Kazarian CM
FAU - Snyder, J Jacob
AU  - Snyder JJ
FAU - Welsh, E R
AU  - Welsh ER
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - AR09D82C7G (Deuterium)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/urine
MH  - Amphetamine/*urine
MH  - *Deuterium
MH  - Gas Chromatography-Mass Spectrometry
MH  - Methamphetamine/*analogs & derivatives/urine
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analogs & derivatives/urine
MH  - Solid Phase Extraction
MH  - Substance Abuse Detection/methods
EDAT- 2011/01/12 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1093/anatox/35.1.15 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2011 Jan;35(1):15-22. doi: 10.1093/anatox/35.1.15.