PMID- 21221498
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20221207
IS  - 2737-5935 (Electronic)
IS  - 0037-5675 (Linking)
VI  - 51
IP  - 12
DP  - 2010 Dec
TI  - Early improvement in type 2 diabetes mellitus post Roux-en-Y gastric bypass in 
      Asian patients.
PG  - 937-43
AB  - INTRODUCTION: Obesity is a growing problem worldwide that is closely related to 
      type 2 diabetes mellitus (T2DM). The Roux-en-Y gastric bypass (RYGBP), a 
      restrictive and malabsorptive bariatric procedure, shows mounting evidence of 
      inducing improvement of T2DM. Few studies, especially those examining the early 
      changes in diabetic parameters, have been done in the Asian population. METHODS: 
      All morbidly obese patients with T2DM undergoing RYGBP at our institution from 
      August 2008 to January 2010 were prospectively studied. Six patients had RYGBP, 
      and one had a laparoscopic sleeve gastrectomy with a duodenojejunal bypass. Data 
      collected included pre- and postoperative 75 g oral glucose tolerance test, daily 
      postoperative fasting plasma glucose, and haemoglobin A1c (HbA1c) pre-operation 
      and at two, four and 12 weeks post operation. RESULTS: After 12 weeks, the mean 
      drop in HbA1c was 2.29 +/- 1.39 percent. The change in HbA1c at four (p is 0.039) 
      and 12 (p is 0.005) weeks showed significant improvements. A significant decrease 
      in diabetic medication usage was observed, with four (57 percent) patients not 
      requiring medications within four weeks. Remission of DM was achieved in two 
      (28.6 percent) patients within 12 weeks. Weight loss by various parameters was 
      significant from two weeks onwards. CONCLUSION: The cure rate of 28.6 percent and 
      an improvement rate of 100 percent of T2DM in morbidly obese Asian patients 
      within 12 weeks post operation are promising. Many patients discontinued their 
      diabetic medications in the immediate postoperative period, even before 
      significant weight loss had occurred, indicating that RYGBP has an effect on 
      hormonal mechanisms that influence glucose homeostasis in the body.
FAU - Kiong, K L
AU  - Kiong KL
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge 
      Road, Singapore 119228.
FAU - Ganesh, R
AU  - Ganesh R
FAU - Cheng, A K
AU  - Cheng AK
FAU - Lekshiminarayanan, R
AU  - Lekshiminarayanan R
FAU - Lim, S C
AU  - Lim SC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/*surgery
MH  - Female
MH  - *Gastric Bypass
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Obesity, Morbid/surgery
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/01/12 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2010 Dec;51(12):937-43.