PMID- 21221609
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 100
IP  - 6
DP  - 2011 Jun
TI  - Anxiety trait in patients with stress-induced cardiomyopathy: a case-control 
      study.
PG  - 523-9
LID - 10.1007/s00392-010-0276-x [doi]
AB  - BACKGROUND: Stress-induced Tako-tsubo cardiomyopathy (TTC) is an acute cardiac 
      syndrome, mimics ST elevation myocardial infarction (STEMI), largely confined to 
      postmenopausal women, frequently precipitated by a stressful event. The 
      pathogenesis of TTC is still unknown. Some authors hypothesized a possible 
      connection between TTC and anxiety disease, but no previous study analyzed the 
      relationship between anxiety trait and TTC. This study sought to assess the 
      potential role of anxiety trait in the development and clinical course of TTC. 
      METHODS: We included in the present prospective case-control study 50 consecutive 
      patients admitted to our Hospital with a diagnosis of TTC according to the Mayo 
      Clinic criteria. Fifty control patients with anterior STEMI matched for clinical 
      characteristics such as age, gender, and hypertension were selected. During the 
      hospitalization, all patients were asked to complete the Spielberger Trait 
      Anxiety Inventory (STAI) scale for measuring self-reported trait anxiety 
      (Trait-A). Outcome measures at follow-up were death, TTC recurrence, and 
      rehospitalization. RESULTS: The mean value of STAI scale was 46 +/- 12 in TTC 
      patients and 45 +/- 14 in STEMI patients (p = 0.815). High-anxiety trait (STAI 
      scale value >/= 40) was documented in 30 (60%) TTC patients and in 26 (52%) STEMI 
      patients (p = 0.387). At multivariate analysis, predictors of TTC were lower peak 
      creatine kinase value (HR 0.999; 95% CI 0.998-0.999; p = 0.018) and an antecedent 
      stressful trigger event (HR 45.487; 95% CI 6.471-319.759; p = 0.001), but anxiety 
      trait was not. There were no differences in outcome measures between TTC patients 
      with or without high-anxiety trait. CONCLUSION: In TTC patients, high-anxiety 
      trait is a common finding but it is not significantly more frequent than in 
      patients with STEMI. Moreover, a high-anxiety trait seems to be neither 
      associated with a worse clinical outcome nor a predictor of TTC. Our study do not 
      support the routine evaluation of anxiety trait in patients with TTC.
FAU - Del Pace, Stefano
AU  - Del Pace S
AD  - Department of Cardiology, Careggi Hospital, University of Florence, Viale 
      Morgagni 85, 50134 Florence, Italy.
FAU - Parodi, Guido
AU  - Parodi G
FAU - Bellandi, Benedetta
AU  - Bellandi B
FAU - Zampini, Linda
AU  - Zampini L
FAU - Venditti, Francesco
AU  - Venditti F
FAU - Ardito, Matilde
AU  - Ardito M
FAU - Antoniucci, David
AU  - Antoniucci D
FAU - Gensini, Gian Franco
AU  - Gensini GF
CN  - Tuscany Registry of Tako-tsubo Cardiomyopathy
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110108
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anxiety Disorders/*complications
MH  - Case-Control Studies
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications
MH  - Prospective Studies
MH  - Psychological Tests
MH  - Takotsubo Cardiomyopathy/*complications
EDAT- 2011/01/12 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/12/23 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1007/s00392-010-0276-x [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2011 Jun;100(6):523-9. doi: 10.1007/s00392-010-0276-x. Epub 
      2011 Jan 8.