PMID- 21223376
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20111117
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 22
IP  - 3
DP  - 2011 May
TI  - Maternal diet during lactation and allergic sensitization in the offspring at age 
      of 5.
PG  - 334-41
LID - 10.1111/j.1399-3038.2010.01114.x [doi]
AB  - The objective of this study was to examine the effect of maternal dietary intake 
      during lactation on allergic sensitization at the age of 5 in children carrying 
      HLA-DQB1-conferred susceptibility to type 1 diabetes. We analyzed data for 652 
      consecutively born children with complete information on maternal diet and 
      allergen-specific immunoglobulin E (IgE) measurements who are participating in 
      the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition and 
      allergy study. Analysis was performed using logistic regression. In models that 
      included the significant uncorrelated dietary variables, maternal intake of 
      butters and saturated fatty acids was associated with increased risk, while 
      margarine was associated with a decreased risk, of sensitization to wheat 
      allergen in the offspring. Maternal intake of potatoes, milks, and margarine and 
      low-fat spreads were associated with decreased risk of sensitization to birch 
      allergen. On the other hand, intake of potatoes decreased the risk, while vitamin 
      C and eggs increased the risk, of cat allergic sensitization. Maternal intake of 
      butters and saturated fatty acids during lactation may increase the risk, while 
      margarines may decrease the risk, of sensitization to wheat allergen in the 
      offspring. Maternal intake of potatoes, milks, and margarines may decrease the 
      risk of sensitization to birch allergen. On the other hand, intake of potatoes 
      may decrease the risk, while vitamin C and eggs may increase the risk, of cat 
      allergic sensitization. These effects may persist regardless of maternal or 
      parental allergic status.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Nwaru, Bright I
AU  - Nwaru BI
AD  - Tampere School of Public Health, University of Tampere, Tampere, Finland. 
      bright.nwaru@uta.fi
FAU - Erkkola, Maijaliisa
AU  - Erkkola M
FAU - Ahonen, Suvi
AU  - Ahonen S
FAU - Kaila, Minna
AU  - Kaila M
FAU - Lumia, Mirka
AU  - Lumia M
FAU - Prasad, Marianne
AU  - Prasad M
FAU - Haapala, Anna-Maija
AU  - Haapala AM
FAU - Kronberg-Kippila, Carina
AU  - Kronberg-Kippila C
FAU - Veijola, Riitta
AU  - Veijola R
FAU - Ilonen, Jorma
AU  - Ilonen J
FAU - Simell, Olli
AU  - Simell O
FAU - Knip, Mikael
AU  - Knip M
FAU - Virtanen, Suvi M
AU  - Virtanen SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110112
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Fatty Acids)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8029-34-3 (Butter)
RN  - 8029-82-1 (Margarine)
SB  - IM
MH  - Allergens/adverse effects/*immunology
MH  - Animals
MH  - Betula/adverse effects/immunology
MH  - Breast Feeding
MH  - Butter
MH  - Cats/immunology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/immunology/prevention & control
MH  - *Diet
MH  - Fatty Acids
MH  - Female
MH  - HLA-DQ Antigens/metabolism
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Hypersensitivity/*epidemiology/immunology
MH  - Immunoglobulin E/blood
MH  - Lactation/*immunology
MH  - Margarine
MH  - Risk
MH  - Triticum/adverse effects/immunology
EDAT- 2011/01/13 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1111/j.1399-3038.2010.01114.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2011 May;22(3):334-41. doi: 
      10.1111/j.1399-3038.2010.01114.x. Epub 2011 Jan 12.