PMID- 21224124
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20191111
IS  - 1078-1439 (Print)
IS  - 1078-1439 (Linking)
VI  - 1
IP  - 6
DP  - 1995 Nov-Dec
TI  - FISH studies of urinary cells of patients with bladder cancer.
PG  - 234-9
AB  - Generally, bladder cancers are characterized by complex and numerous chromosome 
      changes that vary from tumor to tumor. Nevertheless, certain chromosome changes 
      recur with a consistency, (eg, +7, +8, -9, and -Y). In applying fluorescence in 
      situ hybridization (FISH) studies to urinary cells in bladder cancer we chose 
      probes for these chromosomes as well as those for chromosomes 10 and 11. A probe 
      for the X chromosome was used for female patients in place of the Y. In the 
      present study, we show that FISH of urine samples can detect the presence of 
      cancer cells in transitional cell carcinoma (TCC) of the bladder of any grade and 
      stage, including carcinomas in situ (CIS). We analyzed 27 samples from 25 
      patients (three were from the same patient); 24 samples were recurrent or newly 
      diagnosed TCC and 3 were CIS. Our results show that FISH of urine samples is a 
      reliable test for the detection of bladder cancer cells, regardless of the grade 
      and stage of the tumor, and that a correlation appeared to exist between 
      invasiveness of the tumor and the number of abnormalities in such tumor.
FAU - Meloni, A M
AU  - Meloni AM
AD  - Southwest Biomedical Research Institute and Genetrix, Inc. Scottsdale, Arizona, 
      USA.
FAU - Peier, A M
AU  - Peier AM
FAU - Kingsley, K L
AU  - Kingsley KL
FAU - Sandberg, A A
AU  - Sandberg AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
AID - 1078-1439(96)00011-7 [pii]
AID - 10.1016/1078-1439(96)00011-7 [doi]
PST - ppublish
SO  - Urol Oncol. 1995 Nov-Dec;1(6):234-9. doi: 10.1016/1078-1439(96)00011-7.