PMID- 21224525
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20220408
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 18
IP  - 4
DP  - 2011
TI  - Associations between cardio-ankle vascular index and microvascular complications 
      in type 2 diabetes mellitus patients.
PG  - 328-36
AB  - AIM: Type 2 diabetes mellitus (T2DM) is a risk factor for increased arterial 
      stiffness. We evaluated associations between the cardio-ankle vascular index 
      (CAVI) and carotid plaque, intima media thickness (IMT), and diabetic 
      microvascular complications in Korean T2DM patients. METHODS: We conducted a 
      retrospective, cross-sectional study of 320 Korean T2DM patients without a 
      history of macrovascular disease or macroalbuminuria. We measured 24-hour urinary 
      albumin excretion (UAE) levels and performed funduscopic and neuropathy 
      examinations to assess the extent of diabetic microvascular complications. 
      Arterial stiffness was assessed using CAVI. We also measured the ankle-brachial 
      index (ABI), common carotid artery IMT, and carotid beta stiffness index. 
      RESULTS: Among the 320 patients enrolled in this study, 64 (20%) had increased 
      CAVI (>/= 9). We found that CAVI was correlated with systolic blood pressure, pulse 
      pressure, IMT, carotid beta stiffness index, log-transformed UAE, and total 
      cholesterol. In multiple logistic regression analysis, mean IMT and the presence 
      of carotid plaque were independently associated with increased CAVI (>/= 9) 
      (OR=5.77, P < 0.01; OR=5.36, P < 0.001, respectively). Furthermore, an increased 
      CAVI was associated with peripheral neuropathy (OR=2.03, P = 0.03) and 
      microalbuminuria (OR=2.47, P < 0.01) after adjusting for possible confounding 
      variables. CONCLUSIONS: The results of this study suggest that increased CAVI is 
      associated with the presence of arterial plaque, increased IMT, and microvascular 
      complications, such as nephropathy and neuropathy, in T2DM patients.
FAU - Kim, Kwang Joon
AU  - Kim KJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Lee, Byung-Wan
AU  - Lee BW
FAU - Kim, Hyun-Min
AU  - Kim HM
FAU - Shin, Joo Youn
AU  - Shin JY
FAU - Kang, Eun Seok
AU  - Kang ES
FAU - Cha, Bong Soo
AU  - Cha BS
FAU - Lee, Eun Jig
AU  - Lee EJ
FAU - Lim, Sung-Kil
AU  - Lim SK
FAU - Lee, Hyun Chul
AU  - Lee HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110106
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Ankle Brachial Index/statistics & numerical data
MH  - Carotid Artery Diseases/pathology
MH  - Cross-Sectional Studies
MH  - Democratic People's Republic of Korea/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*pathology
MH  - Diabetic Nephropathies
MH  - Humans
MH  - *Microcirculation
MH  - Middle Aged
MH  - Plaque, Atherosclerotic
MH  - Retrospective Studies
MH  - Tunica Intima/pathology
MH  - Vascular Diseases/*diagnosis/etiology/pathology
EDAT- 2011/01/13 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - JST.JSTAGE/jat/5983 [pii]
AID - 10.5551/jat.5983 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2011;18(4):328-36. doi: 10.5551/jat.5983. Epub 2011 Jan 6.