PMID- 21224864
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20211020
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 31
IP  - 4
DP  - 2011 Apr
TI  - Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, 
      resveratrol, and ischemic preconditioning.
PG  - 1003-19
LID - 10.1038/jcbfm.2010.229 [doi]
AB  - Caloric restriction (CR), resveratrol, and ischemic preconditioning (IPC) have 
      been shown to promote protection against ischemic injury in the heart and brain, 
      as well as in other tissues. The activity of sirtuins, which are enzymes that 
      modulate diverse biologic processes, seems to be vital in the ability of these 
      therapeutic modalities to prevent against cellular dysfunction and death. The 
      protective mechanisms of the yeast Sir2 and the mammalian homolog sirtuin 1 have 
      been extensively studied, but the involvement of other sirtuins in ischemic 
      protection is not yet clear. We examine the roles of mammalian sirtuins in 
      modulating protective pathways against oxidative stress, energy depletion, 
      excitotoxicity, inflammation, DNA damage, and apoptosis. Although many of these 
      sirtuins have not been directly implicated in ischemic protection, they may have 
      unique roles in enhancing function and preventing against stress-mediated 
      cellular damage and death. This review will include in-depth analyses of the 
      roles of CR, resveratrol, and IPC in activating sirtuins and in mediating 
      protection against ischemic damage in the heart and brain.
FAU - Morris, Kahlilia C
AU  - Morris KC
AD  - Department of Neurology, Cerebral Vascular Disease Research Center, University of 
      Miami, Miller School of Medicine, Miami, Florida 33101, USA.
FAU - Lin, Hung Wen
AU  - Lin HW
FAU - Thompson, John W
AU  - Thompson JW
FAU - Perez-Pinzon, Miguel A
AU  - Perez-Pinzon MA
LA  - eng
GR  - NS34773/NS/NINDS NIH HHS/United States
GR  - R01 NS045676-06/NS/NINDS NIH HHS/United States
GR  - R01 NS054147/NS/NINDS NIH HHS/United States
GR  - T32 NS007459/NS/NINDS NIH HHS/United States
GR  - NS054147-01/NS/NINDS NIH HHS/United States
GR  - R01 NS034773/NS/NINDS NIH HHS/United States
GR  - R01 NS045676/NS/NINDS NIH HHS/United States
GR  - NS45676-01/NS/NINDS NIH HHS/United States
GR  - R29 NS034773/NS/NINDS NIH HHS/United States
GR  - T32-NS007459-10/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110112
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Antioxidants)
RN  - 0 (SIRT7 protein, human)
RN  - 0 (Stilbenes)
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (SIRT6 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - EC 3.5.1.- (Sirtuins)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Biotransformation
MH  - Brain Ischemia/pathology
MH  - *Caloric Restriction
MH  - Cell Death/drug effects
MH  - DNA Damage
MH  - Humans
MH  - *Ischemic Preconditioning
MH  - Mitochondria/metabolism
MH  - Oxidative Stress/drug effects/physiology
MH  - Resveratrol
MH  - Signal Transduction/physiology
MH  - Sirtuin 1/genetics/physiology
MH  - Sirtuins/genetics/metabolism/*physiology
MH  - Stilbenes/*pharmacology
PMC - PMC3070983
EDAT- 2011/01/13 06:00
MHDA- 2011/05/28 06:00
PMCR- 2012/04/01
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - jcbfm2010229 [pii]
AID - 10.1038/jcbfm.2010.229 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2011 Apr;31(4):1003-19. doi: 10.1038/jcbfm.2010.229. 
      Epub 2011 Jan 12.