PMID- 21225407
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20211020
IS  - 1863-6713 (Electronic)
IS  - 1863-6705 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan
TI  - Simultaneous double thymic carcinoids: a rare initial manifestation of multiple 
      endocrine neoplasia type 1.
PG  - 68-72
LID - 10.1007/s11748-010-0606-y [doi]
AB  - A 53-year-old man was referred to our hospital for treatment of two anterior 
      mediastinal tumors. The anterior mediastinal tumors were resected by thymectomy 
      under the probable diagnosis of double thymomas. The final pathological diagnosis 
      was multiple thymic carcinoids. Although 20%-25% of patients with thymic 
      carcinoid have a family history of multiple endocrine neoplasia type 1 (MEN-1), 
      radiographic screening just after the operation did not detect any endocrine 
      tumors. However, the patient had a urinary calculus 4 months 7 months after the 
      operation. Endocrinological examination then revealed mild hypercalcemia, 
      hypophosphatemia, hyperinsulinemia, and hyperprolactinemia. Radiologically, a 
      parathyroid tumor and a pancreatic tumor were found. The patient was referred to 
      a university hospital and a mutation of MEN-1 gene was detected. The diagnosis of 
      MEN-1 was confirmed about 1 year after the operation.
FAU - Kikuchi, Ryutaro
AU  - Kikuchi R
AD  - Division of Thoracic Surgery, Fukui Red Cross Hospital, 2-4-1 Tsukimi, Fukui 
      918-8506, Japan. cfaqq207@gmail.com
FAU - Mino, Nobuya
AU  - Mino N
FAU - Okamoto, Taku
AU  - Okamoto T
FAU - Matsukura, Tadashi
AU  - Matsukura T
FAU - Hirai, Takashi
AU  - Hirai T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110112
PL  - Japan
TA  - Gen Thorac Cardiovasc Surg
JT  - General thoracic and cardiovascular surgery
JID - 101303952
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Biopsy
MH  - Carcinoid Tumor/*diagnosis/genetics/pathology/surgery
MH  - DNA Mutational Analysis
MH  - Delayed Diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/genetics/pathology/surgery
MH  - Mutation
MH  - Pancreatic Neoplasms/diagnosis
MH  - Parathyroid Neoplasms/diagnosis
MH  - Predictive Value of Tests
MH  - Proto-Oncogene Proteins/genetics
MH  - Radiotherapy, Adjuvant
MH  - Thymectomy
MH  - Thymus Neoplasms/*diagnosis/genetics/pathology/surgery
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2011/01/13 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/13 06:00
PHST- 2009/11/18 00:00 [received]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1007/s11748-010-0606-y [doi]
PST - ppublish
SO  - Gen Thorac Cardiovasc Surg. 2011 Jan;59(1):68-72. doi: 10.1007/s11748-010-0606-y. 
      Epub 2011 Jan 12.