PMID- 21225442
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20221207
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 21
IP  - 4
DP  - 2011 Aug
TI  - Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid 
      arthritis: protective effect of the T allele and T/T genotype at rs360722.
PG  - 359-64
LID - 10.1007/s10165-010-0399-y [doi]
AB  - Rheumatoid arthritis (RA) is a chronic inflammatory disease with a strong genetic 
      contribution to its pathogenesis. Among numerous candidate genes, cytokine gene 
      polymorphisms have been implicated. Interleukin-18 (IL-18) induces production of 
      tumor necrosis factor-alpha and promotes T helper (Th)1-type immune responses. This 
      study investigates the association between IL-18 promoter polymorphisms and RA 
      susceptibility. A total of 2471 Japanese case-control samples (1493 RA patients 
      and 978 healthy controls) were examined. Three haplotype tag single-nucleotide 
      polymorphisms, rs1946518A/C, rs360718T/G, and rs360722T/C, spanning from the 
      5'UTR to intron 1 were genotyped using allelic discrimination with the use of 
      specific TaqMan probes, and three haplotypes (A-T-T, C-T-C, and A-G-C) were 
      determined. Among these polymorphisms, the frequency of the T allele at rs360722, 
      which tags the A-T-T haplotype, was significantly lower in the RA patient group 
      compared with the normal subjects [0.46 versus 0.49, P = 0.0061, Fisher's exact 
      probability test, odds ratio (OR) = 0.85, 95% confidence interval 
      (CI) = 0.75-0.95]. Having the T/T genotype further increased the significance 
      (0.20 versus 0.27, P = 0.0006, OR = 0.72, 95% CI = 0.58-0.86). Therefore, 
      presence of the T allele and T/T genotype at rs360722 reduces the susceptibility 
      of Japanese people to RA.
FAU - Sugiura, Tomoko
AU  - Sugiura T
AD  - Institute of Rheumatology, Tokyo Women's Medical University School of Medicine, 
      10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan.
FAU - Kawaguchi, Yasushi
AU  - Kawaguchi Y
FAU - Ikari, Katsunori
AU  - Ikari K
FAU - Ichida, Hisae
AU  - Ichida H
FAU - Kawamoto, Manabu
AU  - Kawamoto M
FAU - Momohara, Shigeki
AU  - Momohara S
FAU - Hara, Masako
AU  - Hara M
FAU - Yamanaka, Hisashi
AU  - Yamanaka H
LA  - eng
PT  - Journal Article
DEP - 20110112
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
EDAT- 2011/01/13 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/01/13 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1007/s10165-010-0399-y [doi]
PST - ppublish
SO  - Mod Rheumatol. 2011 Aug;21(4):359-64. doi: 10.1007/s10165-010-0399-y. Epub 2011 
      Jan 12.