PMID- 21227009
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20170214
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 38
IP  - 6
DP  - 2010
TI  - Evaluation of the roles of serum vitamin B(12), folate and homocysteine levels in 
      laryngeal squamous cell carcinoma.
PG  - 2047-52
AB  - Metabolic changes in head and neck carcinogenesis are often non-specifically 
      correlated with carcinomas. The study of metabolic disorders can improve the 
      understanding of tumourigenesis at the cellular level. This study was designed to 
      evaluate the role of serum homocysteine, folate, and vitamin B(12) levels in the 
      pathogenesis of laryngeal squamous cell cancer (LSCC) by measuring serum levels 
      in 60 consecutive untreated patients with LSCC and 60 controls (30 smokers and 30 
      non-smokers). Compared with smoker and non-smoker control groups, significantly 
      lower levels of vitamin B(12) were found in patients with LSCC. Folate levels in 
      patients with LSCC were also significantly lower than in the smoker and 
      non-smoker control groups. There were no significant differences in the 
      homocysteine levels between these three groups. Metabolic alterations in vitamin 
      B(12) and folate levels, particularly hypofolataemia, could be associated with 
      the development of LSCC, although further research is required to confirm their 
      roles definitively.
FAU - Gorgulu, O
AU  - Gorgulu O
AD  - Department of Otolaryngology, Adana Numune Research and Training Hospital, Adana, 
      Turkey.
FAU - Selcuk, T
AU  - Selcuk T
FAU - Ozdemir, S
AU  - Ozdemir S
FAU - Sayar, C
AU  - Sayar C
FAU - Beyazit, Y
AU  - Beyazit Y
FAU - Akbas, Y
AU  - Akbas Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Carcinoma, Squamous Cell/*blood
MH  - Case-Control Studies
MH  - Demography
MH  - Folic Acid/*blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Laryngeal Neoplasms/*blood
MH  - Middle Aged
MH  - Vitamin B 12/*blood
EDAT- 2011/01/14 06:00
MHDA- 2011/04/29 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - 10.1177/147323001003800619 [doi]
PST - ppublish
SO  - J Int Med Res. 2010;38(6):2047-52. doi: 10.1177/147323001003800619.