PMID- 21229629
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20110113
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Oct-Dec
TI  - Atelectasis: positive or negative prognostic factor on outcome of patients with 
      non-small cell lung cancer?
PG  - 679-83
AB  - PURPOSE: the aim of this study was to evaluate the influence of atelectasis (AT) 
      on overall survival of patients with non small cell lung cancer (NSCLC). METHODS: 
      the study included patients of both sexes with unresectable stage III and IV 
      NSCLC with good performance status (PS) (ECOG </= 2). Patients were divided into 
      two groups: with AT (AT+) and without AT (AT-): Factors analyzed included sex, 
      age, histologic type, ECOG performance status, stage of disease and treatment 
      modality. Overall survival was estimated according to Kaplan-Meier method, and 
      multivariate analysis was used to identify independent prognostic factors. 
      RESULTS: we evaluated 247 patients (83% males and 17% females); 47/247 (19%) of 
      patients belonged to AT+ group. In this group 21% of patients had stage IIIA, 46% 
      IIIB stage, and 33% IV stage. Overall survival was significantly longer in the 
      AT+ group (15.23 vs. 9.03 months, p=0.001). AT+ patients in stages III and IV had 
      significantly longer overall survival than AT- patients in the same stages 
      (p=0.001, p=0.002, respectively). Multivariate analysis showed that atelectasis 
      (p=0.001), stage of disease (p=0.001), and treatment modality (p=0.005) were 
      independent prognostic factors associated with survival. CONCLUSION: atelectasis 
      is favorable prognostic factor concerning overall survival in patients with 
      NSCLC.
FAU - Tepavac, A
AU  - Tepavac A
AD  - Department of Chemotherapy, Institute of Pulmonary Diseases of Vojvodina, Sremska 
      Kamenica, Medical Faculty, University of Novi Sad, Serbia. occiput5@yahoo.com
FAU - Secen, N
AU  - Secen N
FAU - Sazdanic Velikic, D
AU  - Sazdanic Velikic D
FAU - Popovic, G
AU  - Popovic G
FAU - Perin, B
AU  - Perin B
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Adenocarcinoma/complications/*mortality/therapy
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/complications/*mortality/therapy
MH  - Carcinoma, Squamous Cell/complications/*mortality/therapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/complications/*mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Pulmonary Atelectasis/*diagnosis/*etiology
MH  - Radiotherapy Dosage
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2011/01/14 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PST - ppublish
SO  - J BUON. 2010 Oct-Dec;15(4):679-83.