PMID- 21229683
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110113
IS  - 0021-5252 (Print)
IS  - 0021-5252 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - [Recent advancement in the basic and clinical studies in myasthenia gravis].
PG  - 79-89
AB  - Myasthenia gravis (MG) is an autoimmune disease characterized by fatigable muscle 
      weakness, and autoantibodies to nicotinic acetylcholine receptor (AchR) have been 
      thought to play the key role in the pathogenesis. The recent great progress in 
      the basic research is identification of a novel autoantibody to muscle-specific 
      kinase (MuSK). This discovery led to elucidation of difference in pathogenesis 
      between AchR antibody (+) and MuSK antibody (+) diseases. The recent progress in 
      the clinical practice for MG is introduction of video-assisted thoracic surgery. 
      Less invasive surgery is expected to improve the outcome of thymectomy. At the 
      same time, several immunosuppressants have been shown to be effective for MG. 
      Further progresses in the basic as well as clinical researches are expected to 
      improve the treatment for MG.
FAU - Okumura, Meinoshin
AU  - Okumura M
AD  - Department of General Thoracic Surgery, Osaka University Graduate School of 
      Medicine, Suita, Japan.
FAU - Shiono, Hiroyuki
AU  - Shiono H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Kyobu Geka
JT  - Kyobu geka. The Japanese journal of thoracic surgery
JID - 0413533
SB  - IM
MH  - Humans
MH  - Myasthenia Gravis/drug therapy/surgery/*therapy
EDAT- 2011/01/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - Kyobu Geka. 2011 Jan;64(1):79-89.