PMID- 21232228
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110114
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 3
DP  - 2004 Jun 20
TI  - [A randomized clinical trial of cisplatin solution and cisplatin powder 
      combination regimens in the treatment of patients with lung cancer].
PG  - 243-6
LID - 10.3779/j.issn.1009-3419.2004.03.15 [doi]
AB  - BACKGROUND: To compare the efficacy and side effects between cisplatin solution 
      and cisplatin powder combination regimens for lung cancer. METHODS: A total of 
      223 patients were enrolled into this study. EP protocol was given to patients 
      with small cell lung cancer (SCLC), and NP protocol to non small cell lung cancer 
      (NSCLC). The 223 patients were randomly divided into cisplatin solution group and 
      cisplatin powder group, and the same drugs and dosage were used in the two groups 
      for the same type of lung cancer. RESULTS: Response rates of the cisplatin 
      solution group and the cisplatin powder group were 84.8% and 82.4% for SCLC ( P > 
      0.05), and 31.6% and 29.9% for NSCLC ( P > 0.05), respectively. The major side 
      effects were gastrointestinal reactions and myelosuppression. Significantly 
      higher incidence of nausea/vomiting was found in cisplatin solution group than 
      that in cisplatin powder group for either SCLC or NSCLC ( P < 0.05). There was a 
      remarkable difference in cost of hospitalization between the two groups ( P < 
      0.05). CONCLUSIONS: Cisplatin solution is as effective as cisplatin powder in the 
      treatment of lung cancer. However, the more severe nausea/vomiting reactions and 
      higher cost of cisplatin solution should be considered in its clinical 
      application.
FAU - Ren, Li
AU  - Ren L
AD  - Department of Chemotherapy, Cancer Center, West China Hospital, Sichuan 
      University, Chengdu, Sichuan 610041, P.R.China.
FAU - Yan, Xi
AU  - Yan X
FAU - Gou, Hongfeng
AU  - Gou H
FAU - Qiu, Meng
AU  - Qiu M
FAU - Li, Lu
AU  - Li L
FAU - Zhu, Jiang
AU  - Zhu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/06/20 00:00
MHDA- 2004/06/20 00:01
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2004/06/20 00:00 [pubmed]
PHST- 2004/06/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.03.15 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Jun 20;7(3):243-6. doi: 
      10.3779/j.issn.1009-3419.2004.03.15.