PMID- 21232229
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110114
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 3
DP  - 2004 Jun 20
TI  - [A randomized clinical study on efficacy of Aidi injection combined with 
      chemotherapy in the treatment of advanced non-small cell lung cancer].
PG  - 247-9
LID - 10.3779/j.issn.1009-3419.2004.03.16 [doi]
AB  - BACKGROUND: To compare the therapeutic effect, adverse reaction and effect on 
      immunity of chemotherapy combined Aidi injection (AI) with those of chemotherapy 
      alone in the treatment of advanced non small cell lung cancer (NSCLC). METHODS: 
      Ninety eight cases of advanced NSCLC were randomly divided into two groups, trial 
      group and control group. In the trial group, NP plus AI (60 80 ml) were given 
      intravenously by dissolving in 400 ml of normal saline per day for 8-10 days, 
      while in the control group, only NP chemotherapy was given. Navelbine (25 mg/m(2), 
      d1, 8) and cisplastin (40 mg/m(2), d1-3) were chosen in the chemotherapy. Each 
      patient received at least two cycles of treatment. RESULTS: The effective rate in 
      the trial group and the control group was 53.1% and 44.9% respectively, without 
      significant difference between the two groups ( P > 0.05). But the rate of 
      progression, adverse reactions in bone marrow and digestive tract, and change of 
      immunity in the trial group were all lower than those in the control group ( P < 
      0.05), and the improvement in Karnofsky score in the trial group was higher than 
      that in the control group ( P < 0.05). CONCLUSIONS: Chemotherapy of NP combined 
      with AI shows benefit in the treatment of advanced NSCLC. AI could decrease the 
      influence on immunity and adverse reaction of chemotherapy, and improve the 
      quality of life in patients with NSCLC.
FAU - Wang, Dijin
AU  - Wang D
AD  - Department of Chemotherapy, Jiangxi Tumor Hospital, Nanchang, Jiangxi 330029, 
      P.R.China.
FAU - Chen, Yinglan
AU  - Chen Y
FAU - Ren, Jian
AU  - Ren J
FAU - Cai, Yun
AU  - Cai Y
FAU - Liu, Minzhi
AU  - Liu M
FAU - Zhan, Qinyuan
AU  - Zhan Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/06/20 00:00
MHDA- 2004/06/20 00:01
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2004/06/20 00:00 [pubmed]
PHST- 2004/06/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.03.16 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Jun 20;7(3):247-9. doi: 
      10.3779/j.issn.1009-3419.2004.03.16.